3-Hydroxy-4-methoxyindolomorphinans as delta opioid selective ligands.
作者信息
Smith Trudy A, Thatcher Linn N, Coop Andrew
机构信息
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, USA.
出版信息
Bioorg Med Chem Lett. 2007 Sep 15;17(18):5175-6. doi: 10.1016/j.bmcl.2007.06.087. Epub 2007 Jul 4.
Abstract
Previous studies showed that 4-hydroxy-3-methoxyindolomorphinans had variable delta opioid affinity and selectivity. Herein, we show that the 3,4-dimethoxy analogs possessed similar low affinity, whereas the 3-hydroxy-4-methoxy analogs showed excellent delta opioid affinity and selectivity comparable with the parent indolomorphinans.
摘要
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