Satoh Yoshihide, Ishizuka Ken'ichi, Murakami Toshiki
Department of Physiology, The Nippon Dental University School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan.
Brain Res. 2007 Aug 24;1165:60-70. doi: 10.1016/j.brainres.2007.06.008. Epub 2007 Jun 16.
We study whether the red nucleus (RN) lesion can modify rhythmic jaw movements. Rhythmic jaw movements were induced by repetitive electrical stimulation of the two cortical masticatory areas (area A: the orofacial motor cortex; area P: the insular cortex). Lesions made by applied electric current in the RN were found to influence the rhythmic jaw movements induced by stimulation of A-area. The distance between the maximum and minimum jaw-opening positions was less after the lesions were induced. The duration of rhythmic jaw movements was shorter after lesioning. In contrast, lesions of the RN did not influence rhythmic jaw movements induced by stimulation of the P-area. Next, kainic acid (0.2 microl, lesion group) or phosphate-buffered saline (0.2 microl, control group) was injected into the left RN. Three days after injection, rhythmic jaw movements were induced by repetitive electrical stimulation of the A-area. The distance between the maximum and minimum jaw-opening positions in the lesion group was smaller than in the control group. The rhythmic jaw movements of the lesion group had shorter duration than the control group. These results suggest that the RN is involved in the modification of jaw movements induced by stimulation of the A-area.
我们研究红核（RN）损伤是否会改变节律性下颌运动。通过重复电刺激两个皮质咀嚼区（区域A：口面部运动皮质；区域P：岛叶皮质）来诱发节律性下颌运动。发现通过施加电流在红核造成的损伤会影响由刺激A区所诱发的节律性下颌运动。损伤诱发后，下颌最大开口位置与最小开口位置之间的距离变小。损伤后节律性下颌运动的持续时间缩短。相比之下，红核损伤并不影响由刺激P区所诱发的节律性下颌运动。接下来，将海藻酸（0.2微升，损伤组）或磷酸盐缓冲盐水（0.2微升，对照组）注入左侧红核。注射三天后，通过重复电刺激A区诱发节律性下颌运动。损伤组中下颌最大开口位置与最小开口位置之间的距离小于对照组。损伤组的节律性下颌运动持续时间比对照组短。这些结果表明，红核参与了由刺激A区所诱发的下颌运动的改变。
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