跨膜信号传导工具包中的新变化。

A new twist in the transmembrane signaling tool-kit.

作者信息

Lemmon Mark A, Ferguson Kathryn M

机构信息

Department of Biochemistry & Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

出版信息

Cell. 2007 Jul 27;130(2):213-5. doi: 10.1016/j.cell.2007.07.006.

DOI:10.1016/j.cell.2007.07.006

PMID:17662934

Abstract

In this issue, Schlessinger and his colleagues (Yuzawa et al., 2007) describe crystal structures of the complete extracellular region of the Kit receptor tyrosine kinase, both alone and in complex with its activating ligand, stem cell factor (SCF). The structures explain how SCF drives dimerization of the receptor. They also reveal important receptor-receptor contacts that may explain how several Kit mutations lead to cancer.

摘要

在本期杂志中，施莱辛格及其同事（汤泽等人，2007年）描述了Kit受体酪氨酸激酶完整细胞外区域的晶体结构，该结构既包括其单独状态，也包括与激活配体干细胞因子（SCF）结合的复合物状态。这些结构解释了SCF如何驱动受体二聚化。它们还揭示了重要的受体-受体相互作用，这可能解释了几种Kit突变如何导致癌症。