原发性肝脏恶性肿瘤患儿的移植结局。
Outcomes of transplantation in children with primary hepatic malignancy.
作者信息
Beaunoyer Mona, Vanatta Jason M, Ogihara Makoto, Strichartz Debra, Dahl Gary, Berquist William E, Castillo Ricardo O, Cox Kenneth L, Esquivel Carlos O
机构信息
Divisions of Transplantation, Lucile Salter Packard Children's Hospital and Stanford University School of Medicine, Stanford, CA 94304, USA.
出版信息
Pediatr Transplant. 2007 Sep;11(6):655-60. doi: 10.1111/j.1399-3046.2007.00751.x.
HBL and HCC are the most common hepatic malignancies in children. The role of OLT in children with HCC is still a matter of debate. The aim of this study was to review our experience of OLT for HCC. Medical records of patients (<18 yr) who underwent OLT for HCC were reviewed and compared to children who underwent OLT for HBL and for indications other than malignancy. There were 25 patients: HCC (10 cases) and HBL (15 cases). The actuarial patient survival for HCC at one and five yr was 100% and 83.3%, for the HBL group the survival was 86.7% at both one and five yr, and for indications (n=377) other than malignancy the patient survival for pediatric OLT at our center was 87.7% and 84.7% at one and five yr, respectively. The actuarial recurrence free survival at five yr was 83.3% for HCC and 66.8% for HBL. In conclusion, OLT is a good therapeutic modality for children with HCC and HBL.
肝母细胞瘤（HBL）和肝癌（HCC）是儿童最常见的肝脏恶性肿瘤。肝移植（OLT）在儿童肝癌患者中的作用仍存在争议。本研究的目的是回顾我们对儿童肝癌进行肝移植的经验。对因肝癌接受肝移植的患者（<18岁）的病历进行了回顾，并与因肝母细胞瘤和非恶性疾病接受肝移植的儿童进行了比较。共有25例患者：肝癌（10例）和肝母细胞瘤（15例）。肝癌患者1年和5年的精算生存率分别为100%和83.3%，肝母细胞瘤组1年和5年的生存率均为86.7%，在我们中心，非恶性疾病（n=377）接受儿童肝移植患者1年和5年的生存率分别为87.7%和84.7%。肝癌5年的无复发生存精算率为83.3%，肝母细胞瘤为66.8%。总之，肝移植是儿童肝癌和肝母细胞瘤的一种良好治疗方式。
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