可吸入微粒增强结核分枝杆菌感染的THP-1细胞凋亡及其与杀菌活性的相关性
Enhancement of apoptosis of THP-1 cells infected with Mycobacterium tuberculosis by inhalable microparticles and relevance to bactericidal activity.
作者信息
Yadav Awadh Bihari, Misra Amit
机构信息
Pharmaceutics Division, Central Drug Research Institute, Chhattar Manzil Palace, Lucknow, India.
出版信息
Antimicrob Agents Chemother. 2007 Oct;51(10):3740-2. doi: 10.1128/AAC.00925-07. Epub 2007 Jul 30.
Abstract
The relevance of apoptosis to killing of intracellular Mycobacterium tuberculosis was studied with phorbol-differentiated THP-1 cells. Microparticles containing isoniazid and rifabutin induced intrinsic apoptosis and bacterial killing equivalent to that with dissolved drugs and maximally enhanced purinergic P2 receptor activity, while drug-free microparticles induced apoptosis via a different mechanism without killing bacteria.
摘要
利用佛波醇分化的THP-1细胞研究了细胞凋亡与细胞内结核分枝杆菌杀伤作用的相关性。含有异烟肼和利福布汀的微粒诱导内源性凋亡和细菌杀伤，其效果与溶解药物相当，并最大程度增强嘌呤能P2受体活性，而不含药物的微粒通过不同机制诱导凋亡，但不杀伤细菌。
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