IgA肾病中的血清IgA类抗IgA抗体。

Serum IgA class anti-IgA antibody in IgA nephropathy.

作者信息

Hiki Y, Saitoh M, Kobayashi Y

机构信息

Department of Medicine, School of Nursing and Medicine, Kitasato University, Sagamihara City, Japan.

出版信息

Nephron. 1991;59(4):552-60. doi: 10.1159/000186643.

DOI:10.1159/000186643

PMID:1766493

Abstract

IgA class anti-IgA antibody was sought by an immunoabsorbent technique in sera from patients with IgA nephropathy (IgA-N, n = 62), other forms of primary glomerulonephritis (PGN, n = 41), seropositive rheumatoid arthritis (RF-positive, n = 18) and normal controls (c, n = 50). IgA-N (31%) and RF-positive (56%) patients showed a significant increase in IgA anti-IgA antibody levels. The subclass of IgA anti-IgA antibody was predominantly IgA1 in both IgA-N and RF-positive patients. Size analysis revealed the dimer/monomer ratio to be significantly increased in IgA-N patients compared with that of RF-positive patients (p = 0.03). These results indicate the possible existence of the dimeric form of IgA class anti-IgA antibody in the circulation of IgA-N patients.

摘要

采用免疫吸附技术，在IgA肾病患者（IgA - N，n = 62）、其他原发性肾小球肾炎患者（PGN，n = 41）、血清阳性类风湿关节炎患者（RF阳性，n = 18）及正常对照者（c，n = 50）的血清中寻找IgA类抗IgA抗体。IgA - N患者（31%）和RF阳性患者（56%）的IgA抗IgA抗体水平显著升高。在IgA - N患者和RF阳性患者中，IgA抗IgA抗体的亚类主要为IgA1。大小分析显示，与RF阳性患者相比，IgA - N患者的二聚体/单体比值显著升高（p = 0.03）。这些结果表明，IgA - N患者循环中可能存在IgA类抗IgA抗体的二聚体形式。