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卡波西肉瘤在器官移植中应处于何种地位?

[What position to take for Kaposi's sarcoma in organ transplantation?].

作者信息

Farge D, Frances C

机构信息

Hôpital Saint-Louis, Pavillon Lugol, Paris.

出版信息

Nephrologie. 1991;12(5):245-9.

PMID:1766533
Abstract

Kaposi's Sarcoma (KS) is a tumor of multicentric origin, accounting for 4% of the observed neoplasia among organ transplant recipients. Its exact pathogenesis is still unknown. The diagnosis must be suspected in view of skin and/or subcutaneous tumor lesions with potential visceral involvement, which are easily confirmed by histological examination. Initial staging of the disease in 4 subgroups allows to guide therapy and prognosis. Therapeutic options depend on the transplanted organ and on results of early staging at time of diagnosis and treatment may associate: decrease and/or cessation of immunosuppression, laser therapy, radiotherapy and/or chemotherapy.

摘要

卡波西肉瘤(KS)是一种多中心起源的肿瘤,在器官移植受者中观察到的肿瘤形成中占4%。其确切发病机制尚不清楚。鉴于存在潜在内脏受累的皮肤和/或皮下肿瘤病变,必须怀疑该诊断,组织学检查很容易证实这些病变。该疾病在4个亚组中的初始分期有助于指导治疗和判断预后。治疗选择取决于移植器官以及诊断时早期分期的结果,治疗可能包括:减少和/或停止免疫抑制、激光治疗、放射治疗和/或化疗。

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