Butorov S I, Muntianu V I
Klin Med (Mosk). 2007;85(5):43-7.
The purpose of the study was to assess the effectiveness and safety of long-term application of fenspiride, an anti-inflammatory drug, in patients with chronic obstructive pulmonary disease (COPD) under outpatient conditions. The drug was studied on 24 COPD patients. Fenspiride application resulted in improvement in bronchoobstructive syndrome and external respiration parameters, as well as a significant increase in exercise tolerance. In patients with stable stage I COPD, the use of fenspiride as a part of therapeutic regimen leads to better clinical results than in stage II patients. Long-term application of fenspiride in medium therapeutic doses under outpatient conditions is associated with positive clinical effects and leads to significant improvement in quality of life.
本研究的目的是评估抗炎药物芬司匹利在门诊条件下长期应用于慢性阻塞性肺疾病(COPD)患者的有效性和安全性。对24例COPD患者进行了该药物的研究。应用芬司匹利可改善支气管阻塞综合征和肺外呼吸参数,同时显著提高运动耐力。在稳定期I的COPD患者中,将芬司匹利作为治疗方案的一部分使用,比II期患者能产生更好的临床效果。在门诊条件下长期应用中等治疗剂量的芬司匹利具有积极的临床效果,并能显著改善生活质量。