Ramqvist Torbjörn, Andreasson Kalle, Dalianis Tina
Department of Oncology-Pathology, Karolinska Institutet, Cancer Centrum Karolinska, Stockholm, Sweden.
Expert Opin Biol Ther. 2007 Jul;7(7):997-1007. doi: 10.1517/14712598.7.7.997.
Virus-like particles (VLPs) are self-assembling, non-replicating particles lacking the viral genome that are formed by one or several viral structural proteins. VLPs can be purified after expression in yeast cells, insect cells using baculoviruses, Escherichia coli or mammalian cells. Recently, vaccines based on VLPs have come into focus with the FDA approval of a VLP-based vaccine against human papilloma viruses. However, this application of VLPs is just one of many developments within the VLP field. Other potential applications under development besides vaccines against viruses or cancers also include gene delivery and treatment of different disorders.
病毒样颗粒（VLPs）是由一种或几种病毒结构蛋白形成的自我组装、非复制性颗粒，缺乏病毒基因组。VLPs可在酵母细胞、使用杆状病毒的昆虫细胞、大肠杆菌或哺乳动物细胞中表达后进行纯化。最近，随着美国食品药品监督管理局（FDA）批准一种基于VLPs的人乳头瘤病毒疫苗，基于VLPs的疫苗受到了关注。然而，VLPs的这种应用只是VLP领域众多进展之一。除了针对病毒或癌症的疫苗外，正在开发的其他潜在应用还包括基因递送和治疗不同疾病。
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