接受表皮生长因子受体抑制剂治疗的患者出现获得性睫毛粗长及有症状的眼部外部变化：病例报告及文献综述
Acquired trichomegaly and symptomatic external ocular changes in patients receiving epidermal growth factor receptor inhibitors: case reports and a review of literature.
作者信息
Zhang Grace, Basti Surendra, Jampol Lee M
机构信息
Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
出版信息
Cornea. 2007 Aug;26(7):858-60. doi: 10.1097/ICO.0b013e318064584a.
PURPOSE
To report the external ocular changes in 2 patients receiving epidermal growth factor receptor (EGFR) inhibitors.
METHODS
Retrospective observational case series. Two patients receiving epidermal growth factor inhibitors for metastatic non-small-cell lung carcinoma were followed clinically and with external photographs.
RESULTS
Findings included acneiform facial changes, telangiectasia of eyelid margins, meibomitis, tear film dysfunction, and unusual, hyperpigmented, tortuous eyelashes.
CONCLUSIONS
EGFR inhibitors used in the treatment of certain malignancies can lead to symptomatic adnexal and ocular surface changes. Ophthalmologists should be aware of these to appropriately manage them.
目的
报告2例接受表皮生长因子受体（EGFR）抑制剂治疗患者的眼部外部变化。
方法
回顾性观察病例系列。对2例接受表皮生长因子抑制剂治疗转移性非小细胞肺癌的患者进行临床随访并拍摄眼部外部照片。
结果
发现包括痤疮样面部改变、睑缘毛细血管扩张、睑板腺炎、泪膜功能障碍以及异常的、色素沉着过度的、弯曲的睫毛。
结论
用于治疗某些恶性肿瘤的EGFR抑制剂可导致附属器和眼表出现症状性改变。眼科医生应了解这些情况以便进行适当处理。
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