Roehm Pamela C, Gantz Bruce J
Department of Otolaryngology, New York University School of Medicine, New York, New York, and Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA.
Otol Neurotol. 2007 Aug;28(5):708-14. doi: 10.1097/01.mao.0000281805.44197.ec.
To analyze an optimal management protocol for patients 65 years or older at the time of acoustic neuroma diagnosis.
Retrospective case review.
Tertiary care hospital.
Two hundred sixteen patients with acoustic neuroma 65 years or older at time of diagnosis.
Patients with smaller tumors (<2.5 cm) were followed with serial magnetic resonance imaging. If significant growth occurred, they were treated with surgery. Surgery was performed at initial diagnosis on patients with larger tumors or in selected patients for hearing preservation. Stereotactic radiotherapy was performed for poor surgical candidates and for patient choice.
Measurement of acoustic neuroma growth and tabulation of complications.
One hundred fourteen patients were initially managed by observation, 80 with surgery, and 3 with radiation therapy, with an average follow-up of 35.4 months. For patients in the observation group, average tumor growth was 1.2 mm/yr. Thirty-two patients required crossover to surgery or radiotherapy due to tumor growth (average growth, 4.1 versus 0.3 mm/yr for those remaining in the observation group). One of the patients in the observation group had a complication (0.9%).
Management of acoustic neuromas in elderly patients can be based on size and "biological age" criteria. Surgical treatment can safely be reserved for the few patients who have significant tumor growth.
分析听神经瘤诊断时65岁及以上患者的最佳管理方案。
回顾性病例分析。
三级医疗中心。
216例诊断时年龄在65岁及以上的听神经瘤患者。
肿瘤较小(<2.5 cm)的患者采用系列磁共振成像进行随访。如果肿瘤显著生长,则进行手术治疗。对于肿瘤较大的患者或为了保留听力而选择的患者,在初次诊断时即进行手术。对于手术风险较高的患者以及患者自主选择的情况,采用立体定向放射治疗。
测量听神经瘤的生长情况并统计并发症。
114例患者最初采用观察治疗,80例接受手术治疗,3例接受放射治疗,平均随访35.4个月。观察组患者的肿瘤平均生长速度为1.2 mm/年。32例患者因肿瘤生长需要转而接受手术或放疗(平均生长速度为4.1 mm/年,而观察组中其余患者为0.3 mm/年)。观察组中有1例患者出现并发症(0.9%)。
老年听神经瘤患者的治疗可依据肿瘤大小和“生物学年龄”标准。对于少数肿瘤显著生长的患者,可以安全地采用手术治疗。