Vidarsdottir Solrun, Smeets Paul A M, Eichelsheim Diane L, van Osch Matthias J P, Viergever Max A, Romijn Johannes A, van der Grond Jeroen, Pijl Hanno
Leiden University Medical Center, Department of Endocrinology and Metabolic Disease, C4-83, P.O. Box 9600, 2300 RC, Leiden, Netherlands.
Diabetes. 2007 Oct;56(10):2547-50. doi: 10.2337/db07-0193. Epub 2007 Aug 1.
The hypothalamus plays a critical role in the regulation of energy balance and fuel flux. Glucose ingestion inhibits hypothalamic neuronal activity in healthy humans. We hypothesized that hypothalamic neuronal activity in response to an oral glucose load would be altered in patients with type 2 diabetes.
In this randomized, single blind, case-control study, 7 type 2 diabetic men (BMI 27.9 +/- 2.0 kg/m(2)) and 10 age-matched healthy men (BMI 26.1 +/- 3.2 kg/m(2)) were scanned twice for 38 min on separate days using functional magnetic resonance imaging. After 8 min, they ingested either a glucose solution (75 g in 300 ml water) or water (300 ml).
Glucose ingestion resulted in a prolonged significant blood oxygen level-dependent signal decrease in the upper and lower hypothalamus in healthy subjects but not in diabetic patients.
Glucose ingestion fails to inhibit hypothalamic neuronal activity in patients with type 2 diabetes. Failure of neural circuits to properly adapt to nutrient ingestion may contribute to metabolic imbalance in type 2 diabetic patients.
下丘脑在能量平衡和燃料通量调节中起关键作用。摄入葡萄糖会抑制健康人的下丘脑神经元活动。我们假设，2型糖尿病患者口服葡萄糖负荷后下丘脑神经元活动会发生改变。
在这项随机、单盲、病例对照研究中，7名2型糖尿病男性（体重指数27.9±2.0kg/m²）和10名年龄匹配的健康男性（体重指数26.1±3.2kg/m²）在不同日期使用功能磁共振成像进行两次38分钟的扫描。8分钟后，他们分别摄入葡萄糖溶液（75克溶于300毫升水中）或水（300毫升）。
摄入葡萄糖后，健康受试者下丘脑上下部的血氧水平依赖信号显著降低且持续时间延长，而糖尿病患者则不然。
2型糖尿病患者摄入葡萄糖后无法抑制下丘脑神经元活动。神经回路无法正确适应营养物质摄入可能导致2型糖尿病患者代谢失衡。
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