Xiao Ya Mei, Chen Li Li, Cheng Song, Liu Jiao, Zhao Ru Rong
Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Science, Hunan Normal University, Changsha.
Fen Zi Xi Bao Sheng Wu Xue Bao. 2007 Jun;40(3):196-204.
This paper investigates the features of GSCs in the process of the gonad development of sex reversal in Monopterus albus by the histological methods and the histological immunochemical techniques. In Monopterus albus, the GSCs are located in the gonadal lamellae,which are scattered or accumulated during the female phase. In the intersex and the male,the GSCs are distinguished by two types A and B, both of them differ from the GSCs at the female stage in ultrastructure. It shows that the GSCs existing in the gonadal lamellae are the unique germ family, which owns the capability of mitosis in the differential gonads. The GSCs represent the ovogonia in the female phase, while the spermagonia in the intersex and the male phases. CD49 is the molecular marker for the GSCs at the female stage and the GSCs of type A.
本文采用组织学方法和组织免疫化学技术，研究了黄鳝性逆转性腺发育过程中生殖干细胞（GSCs）的特征。在黄鳝中，生殖干细胞位于性腺薄片中，在雌性阶段呈分散或聚集状态。在雌雄同体和雄性阶段，生殖干细胞分为A、B两种类型，它们在超微结构上均与雌性阶段的生殖干细胞不同。结果表明，存在于性腺薄片中的生殖干细胞是独特的生殖细胞家族，在分化的性腺中具有有丝分裂能力。在雌性阶段，生殖干细胞代表卵原细胞，而在雌雄同体和雄性阶段则代表精原细胞。CD49是雌性阶段生殖干细胞和A型生殖干细胞的分子标志物。
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