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左腹外侧前额叶皮层与记忆的认知控制

Left ventrolateral prefrontal cortex and the cognitive control of memory.

作者信息

Badre David, Wagner Anthony D

机构信息

Helen Wills Neuroscience Institute, 132 Barker Hall, MC3190, UC Berkeley, CA 94720-3190, USA.

出版信息

Neuropsychologia. 2007 Oct 1;45(13):2883-901. doi: 10.1016/j.neuropsychologia.2007.06.015. Epub 2007 Jun 29.

DOI:10.1016/j.neuropsychologia.2007.06.015
PMID:17675110
Abstract

Cognitive control mechanisms permit memory to be accessed strategically, and so aid in bringing knowledge to mind that is relevant to current goals and actions. In this review, we consider the contribution of left ventrolateral prefrontal cortex (VLPFC) to the cognitive control of memory. Reviewed evidence supports a two-process model of mnemonic control, supported by a double dissociation among rostral regions of left VLPFC. Specifically, anterior VLPFC (approximately BA 47; inferior frontal gyrus pars orbitalis) supports controlled access to stored conceptual representations, whereas mid-VLPFC (approximately BA 45; inferior frontal gyrus pars triangularis) supports a domain-general selection process that operates post-retrieval to resolve competition among active representations. We discuss the contribution of these control mechanisms across a range of mnemonic domains, including semantic retrieval, recollection of contextual details about past events, resolution of proactive interference in working memory, and task switching. Finally, we consider open directions for future research into left VLPFC function and the cognitive control of memory.

摘要

认知控制机制使记忆能够被策略性地提取,从而有助于唤起与当前目标和行动相关的知识。在本综述中,我们探讨了左侧腹外侧前额叶皮层(VLPFC)对记忆认知控制的作用。所综述的证据支持一种记忆控制的双过程模型,该模型得到了左侧VLPFC喙部区域之间双重分离的支持。具体而言,前额叶腹外侧前部(大致为BA 47;额下回眶部)支持对存储的概念表征进行控制性提取,而前额叶腹外侧中部(大致为BA 45;额下回三角部)支持一种通用领域的选择过程,该过程在提取后起作用以解决活跃表征之间的竞争。我们讨论了这些控制机制在一系列记忆领域中的作用,包括语义提取、对过去事件背景细节的回忆、工作记忆中前摄干扰的解决以及任务切换。最后,我们考虑了未来关于左侧VLPFC功能和记忆认知控制研究的开放方向。

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