鸡中可变剪接的进化保守性。
Evolutionary conservation of alternative splicing in chicken.
作者信息
Katyal S, Gao Z, Liu R-Z, Godbout R
机构信息
Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta, Canada.
出版信息
Cytogenet Genome Res. 2007;117(1-4):146-57. doi: 10.1159/000103175.
Abstract
Alternative splicing represents a source of great diversity for regulating protein expression and function. It has been estimated that one-third to two-thirds of mammalian genes are alternatively spliced. With the sequencing of the chicken genome and analysis of transcripts expressed in chicken tissues, we are now in a position to address evolutionary conservation of alternative splicing events in chicken and mammals. Here, we compare chicken and mammalian transcript sequences of 41 alternatively-spliced genes and 50 frequently accessed genes. Our results support a high frequency of splicing events in chicken, similar to that observed in mammals.
摘要
可变剪接是调节蛋白质表达和功能的一个重要多样性来源。据估计，三分之一到三分之二的哺乳动物基因会发生可变剪接。随着鸡基因组的测序以及对鸡组织中表达的转录本的分析，我们现在有能力研究鸡和哺乳动物中可变剪接事件的进化保守性。在此，我们比较了41个可变剪接基因和50个常访问基因的鸡和哺乳动物转录本序列。我们的结果支持鸡中剪接事件的高频率，这与在哺乳动物中观察到的情况相似。
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1
Complicated RNA splicing of chicken telomerase reverse transcriptase revealed by profiling cells both positive and negative for telomerase activity.
Gene. 2006 Sep 1;379:33-9. doi: 10.1016/j.gene.2006.04.021. Epub 2006 May 10.
2
Deactivation of phosphorylated and nonphosphorylated rhodopsin by arrestin splice variants.
J Neurosci. 2006 Jan 18;26(3):1036-44. doi: 10.1523/JNEUROSCI.3301-05.2006.
3
Evolutionarily conserved and diverged alternative splicing events show different expression and functional profiles.
Nucleic Acids Res. 2005 Sep 29;33(17):5659-66. doi: 10.1093/nar/gki834. Print 2005.
4
Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor.
Diabetologia. 2005 Nov;48(11):2422-7. doi: 10.1007/s00125-005-1951-8. Epub 2005 Sep 29.
5
Characterisation of the genomic structure of chick Fgf8.
DNA Seq. 2005 Jun;16(3):180-6. doi: 10.1080/10425170500069973.
6
Tissue-specific expression of Fgfr2b and Fgfr2c isoforms, Fgf10 and Fgf9 in the developing chick mandible.
Arch Oral Biol. 2006 Feb;51(2):134-45. doi: 10.1016/j.archoralbio.2005.06.011. Epub 2005 Aug 18.
7
Drebrin E2 is differentially expressed and phosphorylated in parietal cells in the gastric mucosa.
Am J Physiol Gastrointest Liver Physiol. 2005 Aug;289(2):G320-31. doi: 10.1152/ajpgi.00002.2005. Epub 2005 Mar 24.
8
A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system.
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9
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Hum Mol Genet. 2005 Mar 15;14(6):735-45. doi: 10.1093/hmg/ddi069. Epub 2005 Jan 27.
10
Alternative splicing of conserved exons is frequently species-specific in human and mouse.
Trends Genet. 2005 Feb;21(2):73-7. doi: 10.1016/j.tig.2004.12.004.
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