鸡中可变剪接的进化保守性。
Evolutionary conservation of alternative splicing in chicken.
作者信息
Katyal S, Gao Z, Liu R-Z, Godbout R
机构信息
Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta, Canada.
出版信息
Cytogenet Genome Res. 2007;117(1-4):146-57. doi: 10.1159/000103175.
Abstract
Alternative splicing represents a source of great diversity for regulating protein expression and function. It has been estimated that one-third to two-thirds of mammalian genes are alternatively spliced. With the sequencing of the chicken genome and analysis of transcripts expressed in chicken tissues, we are now in a position to address evolutionary conservation of alternative splicing events in chicken and mammals. Here, we compare chicken and mammalian transcript sequences of 41 alternatively-spliced genes and 50 frequently accessed genes. Our results support a high frequency of splicing events in chicken, similar to that observed in mammals.
摘要
可变剪接是调节蛋白质表达和功能的一个重要多样性来源。据估计，三分之一到三分之二的哺乳动物基因会发生可变剪接。随着鸡基因组的测序以及对鸡组织中表达的转录本的分析，我们现在有能力研究鸡和哺乳动物中可变剪接事件的进化保守性。在此，我们比较了41个可变剪接基因和50个常访问基因的鸡和哺乳动物转录本序列。我们的结果支持鸡中剪接事件的高频率，这与在哺乳动物中观察到的情况相似。
相似文献
1
Evolutionary conservation of alternative splicing in chicken.鸡中可变剪接的进化保守性。
Cytogenet Genome Res. 2007;117(1-4):146-57. doi: 10.1159/000103175.
2
Comprehensive splicing graph analysis of alternative splicing patterns in chicken, compared to human and mouse.与人类和小鼠相比，鸡中可变剪接模式的全面剪接图谱分析。
BMC Genomics. 2009 Jul 7;10 Suppl 1(Suppl 1):S5. doi: 10.1186/1471-2164-10-S1-S5.
3
Identification of an alternative splicing isoform of chicken Lmbr1.鉴定鸡 Lmbr1 的一种可变剪接异构体。
Mol Biol Rep. 2011 Oct;38(7):4397-403. doi: 10.1007/s11033-010-0567-3. Epub 2010 Dec 15.
4
Characterising alternate splicing and tissue specific expression in the chicken from ESTs.通过ESTs对鸡的可变剪接和组织特异性表达进行表征。
Cytogenet Genome Res. 2007;117(1-4):268-77. doi: 10.1159/000103188.
5
Conserved developmental alternative splicing of muscleblind-like (MBNL) transcripts regulates MBNL localization and activity.肌肉盲样蛋白（MBNL）转录本的保守发育性可变剪接调节 MBNL 的定位和活性。
RNA Biol. 2010 Jan-Feb;7(1):43-55. doi: 10.4161/rna.7.1.10401. Epub 2010 Jan 21.
6
Integrative analysis of tissue-specific methylation and alternative splicing identifies conserved transcription factor binding motifs.组织特异性甲基化和可变剪接的综合分析确定了保守的转录因子结合基序。
Nucleic Acids Res. 2013 Oct;41(18):8503-14. doi: 10.1093/nar/gkt652. Epub 2013 Jul 24.
7
Changes in alternative splicing of human and mouse genes are accompanied by faster evolution of constitutive exons.人类和小鼠基因可变剪接的变化伴随着组成型外显子更快的进化。
Mol Biol Evol. 2005 Nov;22(11):2198-208. doi: 10.1093/molbev/msi218. Epub 2005 Jul 27.
8
Evolution of Nova-dependent splicing regulation in the brain.大脑中依赖于诺瓦蛋白的剪接调控的进化。
PLoS Genet. 2007 Oct;3(10):1838-47. doi: 10.1371/journal.pgen.0030173. Epub 2007 Aug 27.
9
Genome-wide census and expression profiling of chicken neuropeptide and prohormone convertase genes.鸡神经肽和前激素转化酶基因的全基因组普查和表达谱分析。
Neuropeptides. 2010 Feb;44(1):31-44. doi: 10.1016/j.npep.2009.11.002. Epub 2009 Dec 14.
10
Validation of Alternative Transcript Splicing in Chicken Lines that Differ in Genetic Resistance to Marek's Disease.对马立克氏病遗传抗性不同的鸡品系中可变转录本剪接的验证。
Anim Biotechnol. 2016 Oct;27(4):238-44. doi: 10.1080/10495398.2016.1178139.
引用本文的文献
1
Intrinsic and extrinsic cues time somite progenitor contribution to the vertebrate primary body axis.内在和外在线索时间体节祖细胞对脊椎动物初级体轴的贡献。
Elife. 2024 Jan 9;13:e90499. doi: 10.7554/eLife.90499.
2
Genome-Wide Analysis of Alternative Splicing during Host-Virus Interactions in Chicken.鸡在宿主-病毒相互作用过程中可变剪接的全基因组分析。
Viruses. 2021 Dec 2;13(12):2409. doi: 10.3390/v13122409.
3
4
Sex-specific splicing in Drosophila: widespread occurrence, tissue specificity and evolutionary conservation.果蝇中的性别特异性剪接：广泛存在、组织特异性及进化保守性。
Genetics. 2009 Feb;181(2):421-34. doi: 10.1534/genetics.108.096743. Epub 2008 Nov 17.
5
Novel mRNA isoforms of the sodium channels Na(v)1.2, Na(v)1.3 and Na(v)1.7 encode predicted two-domain, truncated proteins.钠通道Na(v)1.2、Na(v)1.3和Na(v)1.7的新型mRNA亚型编码预测的双结构域截短蛋白。
Neuroscience. 2008 Aug 26;155(3):797-808. doi: 10.1016/j.neuroscience.2008.04.060. Epub 2008 May 6.
本文引用的文献
1
Complicated RNA splicing of chicken telomerase reverse transcriptase revealed by profiling cells both positive and negative for telomerase activity.通过对端粒酶活性呈阳性和阴性的细胞进行分析揭示了鸡端粒酶逆转录酶复杂的RNA剪接。
Gene. 2006 Sep 1;379:33-9. doi: 10.1016/j.gene.2006.04.021. Epub 2006 May 10.
2
Deactivation of phosphorylated and nonphosphorylated rhodopsin by arrestin splice variants.抑制蛋白剪接变体对磷酸化和非磷酸化视紫红质的失活作用。
J Neurosci. 2006 Jan 18;26(3):1036-44. doi: 10.1523/JNEUROSCI.3301-05.2006.
3
Evolutionarily conserved and diverged alternative splicing events show different expression and functional profiles.进化上保守和分化的可变剪接事件表现出不同的表达和功能特征。
Nucleic Acids Res. 2005 Sep 29;33(17):5659-66. doi: 10.1093/nar/gki834. Print 2005.
4
Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor.糖尿病视网膜病变与血管内皮生长因子从抗血管生成异构体向促血管生成异构体的剪接转变有关。
Diabetologia. 2005 Nov;48(11):2422-7. doi: 10.1007/s00125-005-1951-8. Epub 2005 Sep 29.
5
Characterisation of the genomic structure of chick Fgf8.鸡Fgf8基因的基因组结构特征分析
DNA Seq. 2005 Jun;16(3):180-6. doi: 10.1080/10425170500069973.
6
Tissue-specific expression of Fgfr2b and Fgfr2c isoforms, Fgf10 and Fgf9 in the developing chick mandible.Fgfr2b和Fgfr2c亚型、Fgf10和Fgf9在发育中的鸡下颌骨中的组织特异性表达。
Arch Oral Biol. 2006 Feb;51(2):134-45. doi: 10.1016/j.archoralbio.2005.06.011. Epub 2005 Aug 18.
7
Drebrin E2 is differentially expressed and phosphorylated in parietal cells in the gastric mucosa.drebrin E2在胃黏膜壁细胞中存在差异表达和磷酸化。
Am J Physiol Gastrointest Liver Physiol. 2005 Aug;289(2):G320-31. doi: 10.1152/ajpgi.00002.2005. Epub 2005 Mar 24.
8
A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system.威尔姆斯瘤抑制因子Wt1的一种剪接变体是嗅觉系统正常发育所必需的。
Development. 2005 Mar;132(6):1327-36. doi: 10.1242/dev.01682. Epub 2005 Feb 16.
9
The Pax6 isoform bearing an alternative spliced exon promotes the development of the neural retinal structure.携带一个可变剪接外显子的Pax6亚型促进神经视网膜结构的发育。
Hum Mol Genet. 2005 Mar 15;14(6):735-45. doi: 10.1093/hmg/ddi069. Epub 2005 Jan 27.
10
Alternative splicing of conserved exons is frequently species-specific in human and mouse.保守外显子的可变剪接在人类和小鼠中通常具有物种特异性。
Trends Genet. 2005 Feb;21(2):73-7. doi: 10.1016/j.tig.2004.12.004.
Zotero 插件