曲马多对心肌缺血再灌注损伤的影响。

Effects of tramadol on myocardial ischemia-reperfusion injury.

作者信息

Bilir Ayten, Erkasap Nilufer, Koken Tulay, Gulec Sacit, Kaygisiz Ziya, Tanriverdi Belkis, Kurt Imran

机构信息

Department of Anaesthesiology and Reanimation, Osmangazi University, Medical Faculty, Eskisehir, Turkey.

出版信息

Scand Cardiovasc J. 2007 Aug;41(4):242-7. doi: 10.1080/14017430701227747.

DOI:10.1080/14017430701227747

PMID:17680512

Abstract

OBJECTIVES

The aim of the present study was to evaluate the effect of tramadol on isolated rat hearts subjected to global ischemia-reperfusion injury.

DESIGN

Langerdorff perfused isolated rat hearts were subjected to 60 min of global ischemia following 60 min of reperfusion. In group I and III hearts were received tramadol before the onset of ischemia. Following the ischemic period, group II and III hearts were received tramadol infusion. Group I and IV hearts were subjected to saline at the same time point. The myocardial postischemic recovery was compared using hemodynamic, coronary flow, biochemical parameters from coronary effluent, and oxidative stress markers from heart tissue homogenates.

RESULTS

There were significant differences between tramadol and saline used groups in hemodynamic parameters. GPx values of groups I and III were significantly lower than group IV (p<0.05). SOD values of groups I, II and III were higher than group IV (p<0.05). LDH values of groups I and II were significantly lower than groups III and IV (p<0.05).

CONCLUSION

Tramadol provides a cardioprotective effect against myocardial ischemia-reperfusion in isolated rat heart.

摘要

目的

本研究旨在评估曲马多对遭受全心缺血-再灌注损伤的离体大鼠心脏的影响。

设计

采用Langendorff灌注离体大鼠心脏，先灌注60分钟，然后进行60分钟全心缺血，再灌注60分钟。在I组和III组中，心脏在缺血开始前接受曲马多。缺血期后，II组和III组心脏接受曲马多输注。I组和IV组心脏在相同时间点接受生理盐水。使用血流动力学、冠状动脉流量、冠状动脉流出液的生化参数以及心脏组织匀浆的氧化应激标志物比较心肌缺血后恢复情况。