Maxadilan, a PAC1 receptor agonist from sand flies.
作者信息
Lerner Ethan A, Iuga Aurel O, Reddy Vemuri B
机构信息
Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Charlestown, Massachusetts, United States.
出版信息
Peptides. 2007 Sep;28(9):1651-4. doi: 10.1016/j.peptides.2007.06.021. Epub 2007 Jun 28.
Abstract
In 1991, a potent 61 amino acid vasodilator peptide, named maxadilan, was isolated from the salivary glands of the sand fly. Subsequently, it was shown that this peptide specifically and potently activated the mammalian PAC1 receptor, one of the three receptors for PACAP. These studies and the link between maxadilan and leishmaniasis are discussed.
摘要
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