对重度抑郁症细胞因子异常的详细检查。
A detailed examination of cytokine abnormalities in Major Depressive Disorder.
作者信息
Simon N M, McNamara K, Chow C W, Maser R S, Papakostas G I, Pollack M H, Nierenberg A A, Fava M, Wong K K
机构信息
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
出版信息
Eur Neuropsychopharmacol. 2008 Mar;18(3):230-3. doi: 10.1016/j.euroneuro.2007.06.004. Epub 2007 Aug 3.
Abstract
Recent technological advances offer an opportunity to further elucidate the complex cytokine network in Major Depressive Disorder (MDD). Twenty cytokines were simultaneously assessed in 49 individuals with MDD and 49 age and gender matched controls. Multiple pro-inflammatory and two anti-inflammatory cytokines were significantly elevated in the MDD sample, including an antidepressant naïve subset. These data support a generalized chronic inflammatory state in MDD, and implicate additional cytokines and chemokines previously linked to cardiovascular disease.
摘要
近期的技术进步为进一步阐明重度抑郁症（MDD）中复杂的细胞因子网络提供了契机。对49名患有MDD的个体以及49名年龄和性别匹配的对照者同时评估了20种细胞因子。在MDD样本中，多种促炎细胞因子和两种抗炎细胞因子显著升高，包括未经抗抑郁治疗的亚组。这些数据支持MDD中存在全身性慢性炎症状态，并表明之前与心血管疾病相关的其他细胞因子和趋化因子也与之有关。
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本文引用的文献
1
Depressive disorders and immunity: 20 years of progress and discovery.
Brain Behav Immun. 2007 May;21(4):374-83. doi: 10.1016/j.bbi.2007.01.010. Epub 2007 Mar 13.
2
Twenty years of research on cytokine-induced sickness behavior.
Brain Behav Immun. 2007 Feb;21(2):153-60. doi: 10.1016/j.bbi.2006.09.006. Epub 2006 Nov 7.
3
Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress.
Am J Psychiatry. 2006 Sep;163(9):1630-3. doi: 10.1176/ajp.2006.163.9.1630.
4
Predictors of relapse in a prospective study of fluoxetine treatment of major depression.
Am J Psychiatry. 2006 Sep;163(9):1542-8. doi: 10.1176/ajp.2006.163.9.1542.
5
Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy.
J Psychiatr Res. 2007 Apr-Jun;41(3-4):326-31. doi: 10.1016/j.jpsychires.2006.05.013. Epub 2006 Jul 25.
6
Cytokines and serotonin transporter in patients with major depression.
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jul;30(5):899-905. doi: 10.1016/j.pnpbp.2006.01.029. Epub 2006 Mar 6.
7
The many roles of chemokines and chemokine receptors in inflammation.
N Engl J Med. 2006 Feb 9;354(6):610-21. doi: 10.1056/NEJMra052723.
8
Cytokine profiles in women with different subtypes of major depressive disorder.
J Psychiatr Res. 2007 Jan-Feb;41(1-2):152-9. doi: 10.1016/j.jpsychires.2005.11.003. Epub 2005 Dec 20.
9
Cytokines sing the blues: inflammation and the pathogenesis of depression.
Trends Immunol. 2006 Jan;27(1):24-31. doi: 10.1016/j.it.2005.11.006. Epub 2005 Nov 28.
10
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Circ J. 2005 Dec;69(12):1484-9. doi: 10.1253/circj.69.1484.
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