Agostino R, Dinapoli L, Modugno N, Iezzi E, Romanelli P, Berardelli A
Department of Neurological Sciences and Neuromed Institute, University of Rome La Sapienza, Rome, Italy.
J Neurol Neurosurg Psychiatry. 2008 Jan;79(1):76-8. doi: 10.1136/jnnp.2007.122010. Epub 2007 Aug 6.
In Parkinson's disease, unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN), unlike bilateral stimulation, excludes ipsilateral confounding effects so that the contralateral effects of DBS on motor performance can be investigated alone. Because no kinematic study has yet investigated how unilateral STN-DBS affects the performance of a contralateral fast sequential motor act, we performed a kinematic analysis of the movement duration, switching time and spatial accuracy of a motor arm sequence in 10 parkinsonian patients. Patients were studied without dopaminergic therapy and when they were OFF and ON unilateral STN-DBS. We found that unilateral STN-DBS significantly improved movement time of a motor sequence and the switching time from one sequential step to the next, whereas accuracy deteriorated. We conclude that unilateral STN-DBS improves the performance of contralateral sequential arm movements in patients with Parkinson's disease.
在帕金森病中，与双侧刺激不同，对丘脑底核（STN）进行单侧深部脑刺激（DBS）可排除同侧混杂效应，从而能够单独研究DBS对运动表现的对侧效应。由于尚无运动学研究探讨单侧STN-DBS如何影响对侧快速连续运动行为的表现，我们对10例帕金森病患者的运动臂序列的运动持续时间、转换时间和空间准确性进行了运动学分析。在未进行多巴胺能治疗以及患者处于单侧STN-DBS关闭和开启状态时对其进行研究。我们发现，单侧STN-DBS显著改善了运动序列的运动时间以及从一个连续步骤转换到下一个步骤的转换时间，而准确性则下降。我们得出结论，单侧STN-DBS可改善帕金森病患者对侧连续手臂运动的表现。
