新生儿头盔式持续气道正压通气（CPAP）下给予一氧化氮的可行性：一项实验台研究
Feasibility of nitric oxide administration by neonatal helmet-CPAP: a bench study.
作者信息
Trevisanuto Daniele, Doglioni Nicoletta, Micaglio Massimo, Zanardo Vincenzo
机构信息
Pediatric Department, Neonatal Intensive Care Unit, Medical School, University of Padova, Azienda Ospedaliera di Padova, Padova, Italy.
出版信息
Paediatr Anaesth. 2007 Sep;17(9):851-5. doi: 10.1111/j.1460-9592.2007.02297.x.
BACKGROUND
Inhaled nitric oxide (NO) may have a role in the treatment of preterm infants with respiratory failure. We evaluated the feasibility of administering NO therapy by a new continuous positive airway pressure (CPAP) system (neonatal helmet-CPAP).
METHODS
While maintaining a constant total flow of 8, 10, and 12 l.min(-1), NO concentrations were progressively increased to 5, 10, 20, and 40 p.p.m. in the neonatal helmet-CPAP pressure chamber (5 cmH2O). NO, NO2, and O2 concentrations were measured in the pressure chamber and the immediate external environment.
RESULTS
In the chamber, NO2 levels remained low (<or=0.8 p.p.m.) at inhaled therapeutic NO concentrations (5, 10, 20, and 40 p.p.m.). The lower O2 concentrations were 95% at 40 p.p.m. NO levels. Leakage of NO and NO2 to the surrounding environment was negligible.
CONCLUSIONS
NO administration is safe and feasible using the neonatal helmet-CPAP system. This method allows the delivery of accurate NO levels and high O2 concentrations avoiding NO2 accumulation. Further experimental and clinical studies are needed.
背景
吸入一氧化氮（NO）可能在治疗呼吸衰竭的早产儿中发挥作用。我们评估了通过一种新的持续气道正压通气（CPAP）系统（新生儿头盔式CPAP）给予NO治疗的可行性。
方法
在保持总流量分别为8、10和12 l·min⁻¹恒定的情况下，在新生儿头盔式CPAP压力腔（5 cmH₂O）中，将NO浓度逐步增加至5、10、20和40 ppm。在压力腔和紧邻的外部环境中测量NO、NO₂和O₂浓度。
结果
在腔室内，在吸入治疗性NO浓度（5、10、20和40 ppm）时，NO₂水平保持较低（≤0.8 ppm）。在NO水平为40 ppm时，较低的O₂浓度为95%。NO和NO₂向周围环境的泄漏可忽略不计。
结论
使用新生儿头盔式CPAP系统给予NO是安全可行的。这种方法能够提供精确的NO水平和高O₂浓度，避免NO₂积聚。还需要进一步的实验和临床研究。
Zotero 插件