Trevisanuto Daniele, Doglioni Nicoletta, Micaglio Massimo, Zanardo Vincenzo
Pediatric Department, Neonatal Intensive Care Unit, Medical School, University of Padova, Azienda Ospedaliera di Padova, Padova, Italy.
Paediatr Anaesth. 2007 Sep;17(9):851-5. doi: 10.1111/j.1460-9592.2007.02297.x.
Inhaled nitric oxide (NO) may have a role in the treatment of preterm infants with respiratory failure. We evaluated the feasibility of administering NO therapy by a new continuous positive airway pressure (CPAP) system (neonatal helmet-CPAP).
While maintaining a constant total flow of 8, 10, and 12 l.min(-1), NO concentrations were progressively increased to 5, 10, 20, and 40 p.p.m. in the neonatal helmet-CPAP pressure chamber (5 cmH2O). NO, NO2, and O2 concentrations were measured in the pressure chamber and the immediate external environment.
In the chamber, NO2 levels remained low (<or=0.8 p.p.m.) at inhaled therapeutic NO concentrations (5, 10, 20, and 40 p.p.m.). The lower O2 concentrations were 95% at 40 p.p.m. NO levels. Leakage of NO and NO2 to the surrounding environment was negligible.
NO administration is safe and feasible using the neonatal helmet-CPAP system. This method allows the delivery of accurate NO levels and high O2 concentrations avoiding NO2 accumulation. Further experimental and clinical studies are needed.
吸入一氧化氮（NO）可能在治疗呼吸衰竭的早产儿中发挥作用。我们评估了通过一种新的持续气道正压通气（CPAP）系统（新生儿头盔式CPAP）给予NO治疗的可行性。
在保持总流量分别为8、10和12 l·min⁻¹恒定的情况下，在新生儿头盔式CPAP压力腔（5 cmH₂O）中，将NO浓度逐步增加至5、10、20和40 ppm。在压力腔和紧邻的外部环境中测量NO、NO₂和O₂浓度。
在腔室内，在吸入治疗性NO浓度（5、10、20和40 ppm）时，NO₂水平保持较低（≤0.8 ppm）。在NO水平为40 ppm时，较低的O₂浓度为95%。NO和NO₂向周围环境的泄漏可忽略不计。
使用新生儿头盔式CPAP系统给予NO是安全可行的。这种方法能够提供精确的NO水平和高O₂浓度，避免NO₂积聚。还需要进一步的实验和临床研究。
