[维生素D治疗——使用哪种类似物以及何时使用？]

[Vitamin D treatment--which analogs and when?].

作者信息

Martin P-Y, Trombetti A, Stoermann C

机构信息

Service de Néphrologie, Département de Médecine Interne, Hôpitaux Universitaires de Genève, HUG, Genève.

出版信息

Ther Umsch. 2007 May;64(5):237-41. doi: 10.1024/0040-5930.64.5.237.

DOI:10.1024/0040-5930.64.5.237

PMID:17685080

Abstract

Chronic kidney disease is associated with a decreased production of the active metabolite of vitamin D, 1 alpha,25-Dihydroxy-Vitamin D. This decrease has several consequences which are not only restricted to the bones. Indeed, vitamin D has multiple actions which are discussed in this review. Vitamin D substitution is considered early in the treatment of chronic kidney disease but uncertainties about the type of substitution remain. The role of vitamin D analogs are reviewed with emphasis on the comparison between calcitriol and paricalcitol.

摘要

慢性肾脏病与维生素D的活性代谢产物1α,25-二羟基维生素D生成减少有关。这种减少会产生多种后果，且不仅限于骨骼。实际上，维生素D具有多种作用，本文将对此进行讨论。在慢性肾脏病的治疗中，早期即考虑进行维生素D替代治疗，但关于替代类型仍存在不确定性。本文对维生素D类似物的作用进行了综述，重点比较了骨化三醇和帕立骨化醇。