DNA图像细胞计量术的额外应用可改善切缘评估。
Additional use of DNA-image cytometry improves the assessment of resection margins.
作者信息
Handschel Jörg, Oz Döne, Pomjanski Natalia, Depprich Rita, Ommerborn Michelle A, Braunstein Stefan, Kübler Norbert R, Meyer Ulrich, Böcking Alfred
机构信息
Department for Cranio- and Maxillofacial Surgery, Heinrich-Heine-University, Düsseldorf, Germany.
出版信息
J Oral Pathol Med. 2007 Sep;36(8):472-5. doi: 10.1111/j.1600-0714.2007.00564.x.
BACKGROUND
Despite the histopathologic findings of tumor-free margins, patients with oral squamous cell carcinoma (SCC) often suffer from local tumor relapse. The purpose of this study was to determine the prognostic value of DNA-image cytometry in the assessment of resection margins.
METHODS
DNA-image cytometry was performed in 40 SCC patients with histologically tumor-free resection margins. The follow-up period since the tumor resection was at least 3 years.
RESULTS
Twenty patients showed a locoregional relapse of the SCC. Fourteen of these patients had aneuploid cells in DNA-image cytometry. Two patients who were relapse-free revealed aneuploid cells too. The sensitivity of the adjuvant use of DNA-image cytometry was 70% and the positive predictive value was 87.5%.
CONCLUSIONS
The additional use of DNA-image cytometry is a reasonable tool for the assessment of the resection margins of SCCs. DNA-image cytometry could help to find the appropriate treatment option for the patients and thus might improve their prognosis.
背景
尽管组织病理学检查显示切缘无肿瘤，但口腔鳞状细胞癌（SCC）患者仍常出现局部肿瘤复发。本研究的目的是确定DNA图像细胞术在评估切除切缘中的预后价值。
方法
对40例组织学检查切缘无肿瘤的SCC患者进行DNA图像细胞术检测。肿瘤切除后的随访期至少为3年。
结果
20例患者出现SCC局部区域复发。其中14例患者在DNA图像细胞术中检测到非整倍体细胞。2例无复发的患者也检测到非整倍体细胞。辅助使用DNA图像细胞术的敏感性为70%，阳性预测值为87.5%。
结论
额外使用DNA图像细胞术是评估SCC切除切缘的合理工具。DNA图像细胞术有助于为患者找到合适的治疗方案，从而可能改善其预后。
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