精油混合物对紫外线照射氧化的皮肤脂质角鲨烯的抗氧化活性。

Antioxidant activities of essential oil mixtures toward skin lipid squalene oxidized by UV irradiation.

作者信息

Wei Alfreda, Shibamoto Takayuki

机构信息

Department of Environmental Toxicology, University of California, Davis, California, USA.

出版信息

Cutan Ocul Toxicol. 2007;26(3):227-33. doi: 10.1080/15569520701224501.

DOI:10.1080/15569520701224501

PMID:17687687

Abstract

Antioxidant activities of essential oil mixtures--thyme or clove leaf with cinnamon leaf, rose, or parsley seed--toward skin lipid, squalene oxidized by UV irradiation were investigated using the malonaldehyde/gas chromatography assay. At all concentrations (50, 100, or 500 mug/mL) tested, thyme oil mixed with 500 mug/mL clove oil showed over 90% inhibitory effect against malonaldehyde formation. The order of potency of all oils mixed together at 500 mug/mL was thyme/clove leaf (93%) > clove leaf/parsley seed = clove leaf /rose (87%) > thyme/parsley seed (83%) > clove leaf/cinnamon leaf (77%) > thyme/parsley seed (71%) > thyme/cinnamon leaf (7%). In comparison, the inhibitory activities of 500 microg/mL of BHT or alpha-tocopheroltoward malonaldehyde formation were 85% and 76%, respectively. Pro-oxidant effects were observed for some mixtures of thyme with cinnamon leaf or rose oils. The potent antioxidant effects resulting from a mixture of thyme and clove leaf oils may be due to the presence of thymol and eugenol.

摘要

采用丙二醛/气相色谱分析法，研究了百里香或丁香叶与肉桂叶、玫瑰或欧芹籽精油混合物对紫外线照射氧化的皮肤脂质、角鲨烯的抗氧化活性。在所有测试浓度（50、100或500μg/mL）下，与500μg/mL丁香油混合的百里香油对丙二醛形成的抑制作用超过90%。所有精油在500μg/mL混合时的效力顺序为：百里香/丁香叶（93%）＞丁香叶/欧芹籽 = 丁香叶/玫瑰（87%）＞百里香/欧芹籽（83%）＞丁香叶/肉桂叶（77%）＞百里香/肉桂叶（71%）＞百里香/肉桂叶（7%）。相比之下，500μg/mL的丁基羟基甲苯（BHT）或α-生育酚对丙二醛形成的抑制活性分别为85%和76%。观察到百里香与肉桂叶或玫瑰油的某些混合物有促氧化作用。百里香和丁香叶油混合物产生的强大抗氧化作用可能归因于百里香酚和丁香酚的存在。