Volpp P Brian, Han Khanh, Kagan A Robert, Tome Michael
Department of Radiation Oncology, Kaiser Permanente, Los Angeles, CA 90027, USA.
Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1199-204. doi: 10.1016/j.ijrobp.2007.04.058. Epub 2007 Aug 6.
Spinal cord ependymomas are rare tumors, accounting for <2% of all primary central nervous system tumors. This study assessed the treatment outcomes for patients diagnosed with spinal cord ependymomas within the Southern California Kaiser Permanente system.
We studied 23 patients treated with surgery with or without external beam radiotherapy (EBRT). The local and distant control rates and overall survival rates were determined.
The overall local control, overall recurrence, and 9-year overall survival rate was 96%, 17.4%, and 63.9%, respectively.
The results of our study indicate that en bloc gross total resection should be the initial treatment, with radiotherapy reserved primarily for postoperative cases with unfavorable characteristics such as residual tumor, anaplastic histologic features, or piecemeal resection. Excellent local control and overall survival rates can be achieved using modern microsurgical techniques, with or without local radiotherapy.
脊髓室管膜瘤是罕见肿瘤，占所有原发性中枢神经系统肿瘤的比例不到2%。本研究评估了在南加州凯撒医疗系统中被诊断为脊髓室管膜瘤的患者的治疗结果。
我们研究了23例接受手术治疗（有或没有外照射放疗[EBRT]）的患者。确定了局部和远处控制率以及总生存率。
总体局部控制率、总体复发率和9年总生存率分别为96%、17.4%和63.9%。
我们的研究结果表明，整块全切除应作为初始治疗方法，放疗主要保留用于具有不良特征的术后病例，如残留肿瘤、间变组织学特征或分块切除。使用现代显微外科技术，无论是否进行局部放疗，均可实现出色的局部控制率和总生存率。
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