Delpech B
Laboratoire d'oncologie moléculaire, centre Henri-Becquerel, Rouen, France.
Bull Cancer. 1991;78(10):869-900.
The cancer stroma is made of cellular and non cellular formations which grow along with cancer cells to build up a tumor. It comes from inflammatory cells and mesenchymal tissue which are mobilized and modified by factors released by cancer cells which bring about inflammatory cell accumulation, angiogenesis, fibroblast mitosis and extracellular matrix production. The extracellular matrix is altogether a barrier against and supporting to cancer cells. The extracellular matrix is also involved in the storage of growth factors which are bound to glycosaminoglycans. Although they are antinomic in vitro, peptidic factors released by tumor cells seem to have an enhancing effect on tumor growth in vivo. The cancer invasion is mediated through diverse enzyme activities, particularly proteases, which degrade the matrix whose degradation products can facilitate the tumor progression. The anti-cancer activity which is exhibited in vitro by macrophages and lymphocytes is expressed at a low level by tumor-macrophages and lymphocytes in vivo. The cancer associated inflammation has no particular feature which could help to screening or to follow up patients. Several elements of the cancer stroma could be selected as targets for investigative cancer therapy.
癌症基质由细胞和非细胞结构组成，它们与癌细胞一起生长以形成肿瘤。它来源于炎症细胞和间充质组织，这些组织被癌细胞释放的因子动员和修饰，从而导致炎症细胞积聚、血管生成、成纤维细胞有丝分裂和细胞外基质产生。细胞外基质既是癌细胞的屏障，也是对癌细胞的支持。细胞外基质还参与与糖胺聚糖结合的生长因子的储存。尽管肿瘤细胞释放的肽类因子在体外具有矛盾性，但它们似乎在体内对肿瘤生长有促进作用。癌症侵袭是通过多种酶的活性介导的，特别是蛋白酶，它们降解基质，其降解产物可促进肿瘤进展。巨噬细胞和淋巴细胞在体外表现出的抗癌活性在体内肿瘤相关巨噬细胞和淋巴细胞中表达水平较低。癌症相关炎症没有有助于筛查或随访患者的特定特征。癌症基质的几个成分可被选作研究性癌症治疗的靶点。
