女性脂肪组织中的双酚A及其氯化衍生物。
Bisphenol-A and chlorinated derivatives in adipose tissue of women.
作者信息
Fernandez M F, Arrebola J P, Taoufiki J, Navalón A, Ballesteros O, Pulgar R, Vilchez J L, Olea N
机构信息
Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, 18071 Granada, Spain.
出版信息
Reprod Toxicol. 2007 Aug-Sep;24(2):259-64. doi: 10.1016/j.reprotox.2007.06.007. Epub 2007 Jun 26.
Bisphenol-A (BPA) and chlorinated derivatives (Cl(x)BPA) were investigated in adipose tissue of women in Southeast Spain. BPA was above limit of detection (LOD) in 11 out of 20 samples (55%). Among Cl(x)BPA, Cl(2)BPA was the most frequent (80%) and abundant, constituting 94.6% of total chlorinated BPA in adipose tissue. Mean +/- S.D. of BPA, monochloro-BPA (ClBPA), dichloro-BPA (Cl(2)BPA), and trichloro-BPA (Cl(3)BPA) were 5.83 +/- 3.48, 3.05 +/- 0.28, 9.21 +/- 9.26, and 0.74 +/- 0.15 ng/g of adipose tissue, respectively. No tetrachloro-BPA (Cl(4)BPA) was found above LOD. There are no published data on BPA in human adipose tissue or on Cl(x)BPA in adipose tissue or blood, limiting comparisons. BPA levels were similar (w/w) to findings in blood (w/v) in other populations and below levels reported in placenta tissue (w/w). Because of the estrogen mimicking effects of BPA and its Cl(x)BPA, further research is needed to explore their combined effects on human health and trends in human exposure.
对西班牙东南部女性的脂肪组织中的双酚A（BPA）及其氯化衍生物（Cl(x)BPA）进行了研究。20个样本中有11个（55%）的BPA含量高于检测限（LOD）。在Cl(x)BPA中，二氯双酚A（Cl(2)BPA）最为常见（80%）且含量最高，占脂肪组织中总氯化双酚A的94.6%。脂肪组织中BPA、一氯双酚A（ClBPA）、二氯双酚A（Cl(2)BPA）和三氯双酚A（Cl(3)BPA）的平均含量±标准差分别为5.83±3.48、3.05±0.28、9.21±9.26和0.74±0.15 ng/g。未发现四氯双酚A（Cl(4)BPA）含量高于检测限。目前尚无关于人体脂肪组织中BPA或脂肪组织及血液中Cl(x)BPA的公开数据，限制了比较研究。BPA水平（重量/重量）与其他人群血液中的水平（重量/体积）相似，且低于胎盘组织中报告的水平（重量/重量）。由于BPA及其Cl(x)BPA具有雌激素模拟作用，因此需要进一步研究以探索它们对人类健康的综合影响以及人类暴露趋势。
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