Trabacca Antonio, Profice Paolo, Costanza Maria Carmela, Gesualdi Marilena, De Rinaldis Marta
Scientific Institute Eugenio Medea, Association La Nostra Famiglia, OSTUNI (Brindisi), Department of Neurorehabilitation I, Developmental Neurology and Functional Rehabilitation, Ostuni, Italy.
J Child Neurol. 2007 May;22(5):639-41. doi: 10.1177/0883073807302612.
The authors report the case of a child with cerebral palsy and refractory epilepsy who developed nonconvulsive status epilepticus without acute medical cause treated successfully with levetiracetam. In accordance with other studies whose authors hypothesized that aggressive treatment may worsen the prognosis in elderly patients with nonconvulsive status epilepticus, the present authors successfully used a more conservative approach to the treatment of nonconvulsive status epilepticus in their patient. This case suggests that levetiracetam is a useful option for the treatment of nonconvulsive status epilepticus in childhood, in accordance with some authors who have described the anticonvulsant effects of levetiracetam in experimental status epilepticus and in status epilepticus in adults and in children with continuous spike waves during slow sleep.
作者报告了一例患有脑瘫和难治性癫痫的儿童病例,该儿童在无急性医学病因的情况下发生了非惊厥性癫痫持续状态,使用左乙拉西坦成功治疗。与其他作者推测积极治疗可能会使老年非惊厥性癫痫持续状态患者预后恶化的研究一致,本文作者成功地对其患者采用了更保守的非惊厥性癫痫持续状态治疗方法。该病例表明,根据一些作者在实验性癫痫持续状态、成人癫痫持续状态以及慢波睡眠期持续棘慢波儿童癫痫持续状态中描述的左乙拉西坦抗惊厥作用,左乙拉西坦是儿童非惊厥性癫痫持续状态治疗的一个有用选择。