转基因小鼠中的过客基因问题。 - Suppr

The problem of passenger genes in transgenic mice.

作者信息

Lusis Aldons J, Yu Janet, Wang Susanna S

机构信息

Department of Microbiology, Immunology, and Molecular Genetics, UCLA School of Medicine, Los Angeles, CA 90095-1679, USA.

出版信息

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2100-3. doi: 10.1161/ATVBAHA.107.147918. Epub 2007 Aug 9.

DOI:10.1161/ATVBAHA.107.147918

PMID:17690316

Abstract

摘要

相似文献

The problem of passenger genes in transgenic mice.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2100-3. doi: 10.1161/ATVBAHA.107.147918. Epub 2007 Aug 9.

Distorted Mendelian transmission as a function of genetic background in Rai1-haploinsufficient mice.

Eur J Med Genet. 2009 Jul-Aug;52(4):224-8. doi: 10.1016/j.ejmg.2008.12.002. Epub 2008 Dec 24.

[Transgenerational transmission of bovine satellite DNA in transgenic mice].

Tsitologiia. 2006;48(6):522-9.

[Molecular models of disease. Transgenes and knockout].

Dtsch Med Wochenschr. 1997 Dec 5;122(49):1527-30. doi: 10.1055/s-0029-1233750.

Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice.

J Leukoc Biol. 2008 Feb;83(2):430-3. doi: 10.1189/jlb.0807585. Epub 2007 Oct 30.

No effect of C-reactive protein on early atherosclerosis in LDLR-/- / human C-reactive protein transgenic mice.

Thromb Haemost. 2008 Jan;99(1):196-201. doi: 10.1160/TH07-10-0595.

Genes and physiology: molecular physiology in genetically engineered animals.

J Clin Invest. 1996 Feb 15;97(4):901-9. doi: 10.1172/JCI118512.

[New ideas in the study of gene function].

Sheng Li Ke Xue Jin Zhan. 2003 Jan;34(1):55-7.

Surviving a knockout blow.

Nature. 2002 Jan 3;415(6867):8-9. doi: 10.1038/415008a.

Behavioural analysis of congenic mouse strains confirms stress-responsive Loci on chromosomes 1 and 12.

Behav Genet. 2008 Jul;38(4):407-16. doi: 10.1007/s10519-008-9206-3. Epub 2008 Apr 1.

引用本文的文献

Transcriptomic analysis reinforces the implication of spatacsin in neuroinflammation and neurodevelopment.

Sci Rep. 2025 Jan 18;15(1):2370. doi: 10.1038/s41598-025-86337-9.

Conditional deletion of in smooth muscle cells does not reduce early atherosclerosis in mice.

Atheroscler Plus. 2023 Dec 20;55:12-20. doi: 10.1016/j.athplu.2023.12.004. eCollection 2024 Mar.

Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading.

Int J Mol Sci. 2022 Apr 15;23(8):4384. doi: 10.3390/ijms23084384.

Mouse background genetics in biomedical research: The devil's in the details.

Transfusion. 2021 Oct;61(10):3017-3025. doi: 10.1111/trf.16628. Epub 2021 Sep 3.

A Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice.

iScience. 2020 Nov 27;23(12):101870. doi: 10.1016/j.isci.2020.101870. eCollection 2020 Dec 18.

Influence of allelic differences in Down syndrome.

Prog Brain Res. 2020;251:29-54. doi: 10.1016/bs.pbr.2019.09.001. Epub 2019 Oct 24.

Confirmation of Ath26 locus on chromosome 17 and identification of Cyp4f13 as an atherosclerosis modifying gene.

Atherosclerosis. 2019 Jul;286:71-78. doi: 10.1016/j.atherosclerosis.2019.05.007. Epub 2019 May 9.

Palmoplantar keratoderma in Slurp1/Slurp2 double-knockout mice.

J Dermatol Sci. 2018 Jan;89(1):85-87. doi: 10.1016/j.jdermsci.2017.08.014. Epub 2017 Sep 28.

High-Speed Mouse Backcrossing Through the Female Germ Line.

PLoS One. 2016 Dec 7;11(12):e0166822. doi: 10.1371/journal.pone.0166822. eCollection 2016.

Applications and Limitations of Mouse Models for Understanding Human Atherosclerosis.

Cell Metab. 2017 Feb 7;25(2):248-261. doi: 10.1016/j.cmet.2016.11.001. Epub 2016 Dec 1.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

相似文献

The problem of passenger genes in transgenic mice.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2100-3. doi: 10.1161/ATVBAHA.107.147918. Epub 2007 Aug 9.

Distorted Mendelian transmission as a function of genetic background in Rai1-haploinsufficient mice.

Eur J Med Genet. 2009 Jul-Aug;52(4):224-8. doi: 10.1016/j.ejmg.2008.12.002. Epub 2008 Dec 24.

[Transgenerational transmission of bovine satellite DNA in transgenic mice].

Tsitologiia. 2006;48(6):522-9.

[Molecular models of disease. Transgenes and knockout].

Dtsch Med Wochenschr. 1997 Dec 5;122(49):1527-30. doi: 10.1055/s-0029-1233750.

Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice.

J Leukoc Biol. 2008 Feb;83(2):430-3. doi: 10.1189/jlb.0807585. Epub 2007 Oct 30.

No effect of C-reactive protein on early atherosclerosis in LDLR-/- / human C-reactive protein transgenic mice.

Thromb Haemost. 2008 Jan;99(1):196-201. doi: 10.1160/TH07-10-0595.

Genes and physiology: molecular physiology in genetically engineered animals.

J Clin Invest. 1996 Feb 15;97(4):901-9. doi: 10.1172/JCI118512.

[New ideas in the study of gene function].

Sheng Li Ke Xue Jin Zhan. 2003 Jan;34(1):55-7.

Surviving a knockout blow.

Nature. 2002 Jan 3;415(6867):8-9. doi: 10.1038/415008a.

Behavioural analysis of congenic mouse strains confirms stress-responsive Loci on chromosomes 1 and 12.

Behav Genet. 2008 Jul;38(4):407-16. doi: 10.1007/s10519-008-9206-3. Epub 2008 Apr 1.

引用本文的文献

Transcriptomic analysis reinforces the implication of spatacsin in neuroinflammation and neurodevelopment.

Sci Rep. 2025 Jan 18;15(1):2370. doi: 10.1038/s41598-025-86337-9.

Conditional deletion of in smooth muscle cells does not reduce early atherosclerosis in mice.

Atheroscler Plus. 2023 Dec 20;55:12-20. doi: 10.1016/j.athplu.2023.12.004. eCollection 2024 Mar.

Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading.

Int J Mol Sci. 2022 Apr 15;23(8):4384. doi: 10.3390/ijms23084384.

Mouse background genetics in biomedical research: The devil's in the details.

Transfusion. 2021 Oct;61(10):3017-3025. doi: 10.1111/trf.16628. Epub 2021 Sep 3.

A Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice.

iScience. 2020 Nov 27;23(12):101870. doi: 10.1016/j.isci.2020.101870. eCollection 2020 Dec 18.

Influence of allelic differences in Down syndrome.

Prog Brain Res. 2020;251:29-54. doi: 10.1016/bs.pbr.2019.09.001. Epub 2019 Oct 24.

Confirmation of Ath26 locus on chromosome 17 and identification of Cyp4f13 as an atherosclerosis modifying gene.

Atherosclerosis. 2019 Jul;286:71-78. doi: 10.1016/j.atherosclerosis.2019.05.007. Epub 2019 May 9.

Palmoplantar keratoderma in Slurp1/Slurp2 double-knockout mice.

J Dermatol Sci. 2018 Jan;89(1):85-87. doi: 10.1016/j.jdermsci.2017.08.014. Epub 2017 Sep 28.

High-Speed Mouse Backcrossing Through the Female Germ Line.

PLoS One. 2016 Dec 7;11(12):e0166822. doi: 10.1371/journal.pone.0166822. eCollection 2016.

Applications and Limitations of Mouse Models for Understanding Human Atherosclerosis.

Cell Metab. 2017 Feb 7;25(2):248-261. doi: 10.1016/j.cmet.2016.11.001. Epub 2016 Dec 1.

The problem of passenger genes in transgenic mice.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献