利奈唑胺和万古霉素对表皮葡萄球菌生物被膜的活性及穿透性
[Activity and penetration of linezolid and vancomycin against Staphylococcus epidermidis biofilms].
作者信息
Rodríguez-Martínez José M, Ballesta Sofía, García Isabel, Conejo M Carmen, Pascual Alvaro
机构信息
Departamento de Microbiología, Universidad de Sevilla, España.
出版信息
Enferm Infecc Microbiol Clin. 2007 Aug-Sep;25(7):425-8. doi: 10.1157/13108705.
INTRODUCTION
The activity and capacity for penetration of linezolid and vancomycin were comparatively evaluated against Staphylococcus epidermidis biofilms.
METHODS
The activity of linezolid versus vancomycin was assessed against 24-hour S. epidermidis biofilms developed on silicon catheters. Penetration of the two antimicrobial agents was measured in biofilms developed on polycarbonate membrane filters. Penetration and activity were comparatively tested using S. epidermidis, slime-producing and non-slime-producing strains.
RESULTS
The activity of linezolid against S. epidermidis biofilms was significantly greater than that of vancomycin for both strains. Neither antimicrobial completely eradicated bacterial survival in 24-hour biofilms. Linezolid penetration in biofilms was greater than that of vancomycin for both S. epidermidis strains.
CONCLUSIONS
Linezolid showed higher in vitro activity than vancomycin against S. epidermidis biofilms on silicone catheters. This effect may be due to the capability of linezolid to cross the bacterial biofilm.
引言
对利奈唑胺和万古霉素针对表皮葡萄球菌生物被膜的活性及穿透能力进行了比较评估。
方法
评估利奈唑胺与万古霉素针对在硅胶导管上形成的24小时表皮葡萄球菌生物被膜的活性。在聚碳酸酯膜滤器上形成的生物被膜中测量这两种抗菌剂的穿透情况。使用表皮葡萄球菌、产黏液和不产黏液菌株对穿透和活性进行比较测试。
结果
对于两种菌株，利奈唑胺针对表皮葡萄球菌生物被膜的活性均显著高于万古霉素。两种抗菌剂均未完全根除24小时生物被膜中的细菌存活情况。对于两种表皮葡萄球菌菌株，利奈唑胺在生物被膜中的穿透均高于万古霉素。
结论
利奈唑胺在体外针对硅胶导管上的表皮葡萄球菌生物被膜显示出比万古霉素更高的活性。这种效应可能归因于利奈唑胺穿过细菌生物被膜的能力。
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