新型砜连接双杂环的合成与抗菌活性
Synthesis and antimicrobial activity of novel sulfone-linked bis heterocycles.
作者信息
Padmavathi V, Thriveni P, Sudhakar Reddy G, Deepti D
机构信息
Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, India.
出版信息
Eur J Med Chem. 2008 May;43(5):917-24. doi: 10.1016/j.ejmech.2007.06.011. Epub 2007 Jul 6.
PMID:17692433
Abstract
Novel sulfone-linked bis heterocycles pyrazolines in combination with thiadiazoles, oxadiazoles and triazoles were prepared from E-styrylsulfonylacetic acid methyl ester and tested for their antimicrobial activity. The compound 8 showed pronounced activity than the compounds 6 and 7.
摘要
由E-苯乙烯基磺酰基乙酸甲酯制备了新型砜连接的双杂环吡唑啉与噻二唑、恶二唑和三唑的组合，并对其抗菌活性进行了测试。化合物8表现出比化合物6和7更显著的活性。
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