Uemura Hideki, Kagisaki Koji, Adachi Iki, Takeda Koji, Hagino Ikuo, Yagihara Toshikatsu, Kitamura Soichiro
Department of Cardio-thoracic Surgery and Cardiac Morphology, Royal Brompton Hospital, London, UK.
Int J Cardiol. 2008 Sep 16;129(1):26-31. doi: 10.1016/j.ijcard.2007.05.034. Epub 2007 Aug 13.
To determine how often the aortic valve is involved in doubly-committed ventricular septal defect in a surgical series, and when to intervene to minimize aortic valvar impediments.
The defect was surgically closed in 415 patients via the pulmonary trunk, age at operation ranging from 2 months to 76 years old. In infants, pulmonary hypertension or pulmonary high flow was the exclusive indication. Any progressive deformity of the aortic leaflet or aortic regurgitation was an alternative principal indication in older children or adolescents. No additional manoeuvres were employed for the aortic root unless aortic regurgitation is more than slight. Otherwise, the aortic valve was repaired or replaced. When the sinus of Valsalva was significantly deformed or ruptured, the structure was surgically restored.
Significant aortic regurgitation or the ruptured sinus of Valsalva was increasingly found beyond the paediatric age. Bacterial endocarditis was seen in 8% of adults or adolescents. Silent herniation of the aortic leaflet was not uncommon after 4 years old, seen in more than 40% of patients. Need of aortic valvar repair was rare before 2 years old, and in approximately 10% between 2 and 15 years old. Freedom from reoperation was 89% at 10 years and 78% at 25 years after aortic valvar repair, and 91% and 84%, respectively, after replacement, versus 100% and 99.4%, respectively, after no additional valvar procedure.
Aortic valvar involvement was rare, and ventricular septal defect was closed without impediments, before 2 years old. Surgery should be arranged before any additional aortic valvar manoeuvre is needed.
确定在一组手术病例中主动脉瓣受累于双动脉干下室间隔缺损的频率,以及何时进行干预以尽量减少主动脉瓣的阻碍。
415例患者经肺动脉干进行手术闭合缺损,手术年龄从2个月至76岁。在婴儿中,肺动脉高压或肺高流量是唯一的手术指征。主动脉瓣叶的任何进行性畸形或主动脉反流是大龄儿童或青少年的另一个主要手术指征。除非主动脉反流超过轻度,否则不对主动脉根部进行额外操作。否则,对主动脉瓣进行修复或置换。当主动脉窦明显变形或破裂时,对该结构进行手术修复。
在儿科年龄以上越来越多地发现显著的主动脉反流或主动脉窦破裂。在成人或青少年中,8%的患者发生细菌性心内膜炎。4岁以后,主动脉瓣叶隐匿性脱垂并不少见,超过40%的患者可见。2岁以前很少需要进行主动脉瓣修复,2至15岁之间约为10%。主动脉瓣修复术后10年再次手术率为89%,25年为78%;置换术后分别为91%和84%;未进行额外瓣膜手术的患者分别为100%和99.4%。
在两岁之前,主动脉瓣受累情况罕见,室间隔缺损可顺利闭合。应在需要进行任何额外的主动脉瓣操作之前安排手术。