从胎儿干细胞到成体干细胞的转变：敲除Sox17基因。
Fetal to adult stem cell transition: knocking Sox17 off.
作者信息
Jang Yoon-Young, Sharkis Saul J
机构信息
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
出版信息
Cell. 2007 Aug 10;130(3):403-4. doi: 10.1016/j.cell.2007.07.027.
PMID:17693249
Abstract
What controls the inherent differences between fetal and adult hematopoietic stem cells (HSCs)? In this issue of Cell, Kim et al. (2007) demonstrate in mice that the endodermal transcription factor Sox17 is required for the maintenance of fetal and neonatal but not adult HSCs.
摘要
是什么控制着胎儿和成人造血干细胞（HSCs）之间的固有差异？在本期《细胞》杂志中，Kim等人（2007年）在小鼠身上证明，内胚层转录因子Sox17是维持胎儿和新生儿造血干细胞所必需的，但对成人造血干细胞并非如此。
Zotero 插件