Mark C
Medical Products Agency, Dep. Laboratory, Box 26, S-751 03 Uppsala, Sweden.
Pharmeur Sci Notes. 2006 Aug;2006(1):27-9.
Since influenza vaccines are propagated in embryonated chicken eggs, they contain residual egg proteins (mostly ovalbumin). This could lead to the induction of allergic reactions in vaccinated individuals that are allergic to egg. The ovalbumin content in six influenza vaccines, available on the Swedish market in the autumn of 2004, was studied using a commercial ELISA kit. The results show a high degree of variation in ovalbumin content between the different influenza vaccines, ranging between 28 ng/ml and 1.1 microg/ml. No vaccine, however, had an ovalbumin concentration above the limit of 1.0 microg per dose (i.e. 2.0 microg/ml) set by the European Pharmacopoeia for the actual types of influenza vaccines. Thus results presented here clearly show that a tightening of the limit is fully possible.
由于流感疫苗是在鸡胚中繁殖的，所以它们含有残留的鸡蛋蛋白（主要是卵清蛋白）。这可能会导致对鸡蛋过敏的接种者产生过敏反应。2004年秋季在瑞典市场上可获得的六种流感疫苗中的卵清蛋白含量，使用商用酶联免疫吸附测定试剂盒进行了研究。结果显示，不同流感疫苗之间的卵清蛋白含量差异很大，范围在28纳克/毫升至1.1微克/毫升之间。然而，没有一种疫苗的卵清蛋白浓度超过欧洲药典针对实际流感疫苗类型设定的每剂1.0微克（即2.0微克/毫升）的限值。因此，这里呈现的结果清楚地表明完全有可能收紧该限值。
