al-Abadi H, Nagel R
Urologische Klinik und Poliklinik, Universitätsklinikum Rudolf Virchow, Standort Charlottenburg, Freie Universität Berlin.
Helv Chir Acta. 1991 Sep;58(3):331-4.
In 157 patients with renal cell carcinoma, the ploidy, DNA heterogeneity and the phases of the cell cycle occurring in the tumors were determined by means of single-cell DNA cytophotometry, in order to establish further prognostic factors in addition to the ones known so far (stage/grade). Patients with aneuploid tumors or tumors with more than one DNA frequency peak were found to have lymph node metastases intraoperatively and died earlier than patients with diploid tumors. Patients who had tumors with low proliferative activity survived longer than patients with highly proliferative tumor activity (p = 0.001).
对157例肾细胞癌患者，采用单细胞DNA细胞光度测定法测定肿瘤的倍性、DNA异质性及细胞周期各时相，以确定除目前已知的预后因素（分期/分级）之外的其他预后因素。发现非整倍体肿瘤患者或具有一个以上DNA频率峰的肿瘤患者术中出现淋巴结转移，且比二倍体肿瘤患者死亡更早。肿瘤增殖活性低的患者比肿瘤增殖活性高的患者存活时间更长（p = 0.001）。
