噪声暴露对衰老耳朵的影响。

The effect of noise exposure on the aging ear.

作者信息

Shone G, Altschuler R A, Miller J M, Nuttall A L

机构信息

Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109-0506.

出版信息

Hear Res. 1991 Nov;56(1-2):173-8. doi: 10.1016/0378-5955(91)90167-8.

DOI:10.1016/0378-5955(91)90167-8

PMID:1769911

Abstract

The effect of noise exposure on auditory sensitivity and inner ear morphology was compared in aged and young mature mice. Hearing thresholds were obtained by auditory evoked brain stem responses (ABR) before and after noise exposure, and hair cell loss was quantified. The study was done in two parts: first to assess the effect of noise exposure on subjects with presbycusis, and second to assess its effect on aged subjects without measurable presbycusis. In the first experiment C57BL/6 mice, with an age-related hearing loss, were used as a model for presbycusis. C57BL/6 mice exhibiting presbycusis were more susceptible to noise injury than age-matched CBA/Ca mice. In the second experiment CBA/Ca mice were used. These mice retain normal hearing even with advancing age. The aged CBA/Ca mice had the same susceptibility to noise injury as young CBA/Ca mice.

摘要

在老年和年轻成熟小鼠中比较了噪声暴露对听觉敏感性和内耳形态的影响。在噪声暴露前后通过听觉诱发脑干反应（ABR）获得听力阈值，并对毛细胞损失进行量化。该研究分为两部分：第一部分评估噪声暴露对患有老年性耳聋的受试者的影响，第二部分评估其对无明显老年性耳聋的老年受试者的影响。在第一个实验中，将患有与年龄相关听力损失的C57BL/6小鼠用作老年性耳聋的模型。表现出老年性耳聋的C57BL/6小鼠比年龄匹配的CBA/Ca小鼠更容易受到噪声损伤。在第二个实验中使用了CBA/Ca小鼠。这些小鼠即使随着年龄增长仍保持正常听力。老年CBA/Ca小鼠对噪声损伤的易感性与年轻CBA/Ca小鼠相同。