Mitalas Litza E, Gosselink Martijn P, Zimmerman David D E, Schouten W Ruud
Colorectal Research Group Rotterdam, Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.
Dis Colon Rectum. 2007 Oct;50(10):1508-11. doi: 10.1007/s10350-007-9015-4.
Transanal advancement flap repair (TAFR) has been advocated as the treatment of choice for transsphincteric fistulas passing through the upper or middle third of the external anal sphincter. It is not clear whether previous attempts at repair adversely affect the outcome of TAFR. The purpose of the present study was to evaluate the success rate of a repeat TAFR and to assess the impact of such a second procedure on the overall healing rate of high transsphincteric fistulas and on fecal continence.
Between January 2001 and January 2005, a consecutive series of 87 patients (62 males; median age, 49 (range, 27-73) years) underwent TAFR. Median follow-up was 15 (range, 2-50) months. Patients in whom the initial operation failed were offered two further treatment options: a second flap repair or a long-term indwelling seton drainage. Twenty-six patients (male:female ratio, 5:2; median age, 51 (range, 31-72) years) preferred a repeat repair. Continence status was evaluated before and after the procedures by using the Rockwood Faecal Incontinence Severity Index (RFISI).
The healing rate after the first TAFR was 67 percent. Of the 29 patients in whom the initial procedure failed, 26 underwent a repeat TAFR. The healing rate after this second procedure was 69 percent, resulting in an overall success rate of 90 percent. Both before and after the first attempt of TAFR, the median RFISI was 7 (range, 0-34). In patients who underwent a second TAFR, the median RFISI before and after this procedure was 9 (range, 0-34) and 8 (range, 0-34), respectively. None of these changes were statistically significant.
Repeat TAFR increases the overall healing rate of high transsphincteric fistulas from 67 percent after one attempt to 90 percent after two attempts without a deteriorating effect on fecal continence.
经肛门推进皮瓣修复术(TAFR)已被提倡作为治疗穿过肛门外括约肌上三分之一或中三分之一的经括约肌瘘的首选方法。既往修复尝试是否会对TAFR的结果产生不利影响尚不清楚。本研究的目的是评估重复TAFR的成功率,并评估第二次手术对高位经括约肌瘘的总体愈合率和大便失禁的影响。
在2001年1月至2005年1月期间,连续87例患者(62例男性;中位年龄49岁(范围27 - 73岁))接受了TAFR。中位随访时间为15个月(范围2 - 50个月)。初次手术失败的患者有另外两种治疗选择:第二次皮瓣修复或长期留置挂线引流。26例患者(男女比例5:2;中位年龄51岁(范围31 - 72岁))选择重复修复。通过使用罗克伍德大便失禁严重程度指数(RFISI)在手术前后评估大便失禁状态。
首次TAFR后的愈合率为67%。在初次手术失败的29例患者中,26例接受了重复TAFR。第二次手术后的愈合率为69%,总体成功率为90%。在首次TAFR尝试之前和之后,中位RFISI均为7(范围0 - 34)。在接受第二次TAFR的患者中,该手术前后的中位RFISI分别为9(范围0 - 34)和8(范围0 - 34)。这些变化均无统计学意义。
重复TAFR可使高位经括约肌瘘的总体愈合率从一次尝试后的67%提高到两次尝试后的90%,且对大便失禁无恶化影响。