原发性血小板增多症合并急性冠状动脉综合征患者的治疗挑战。

Challenges in the treatment of patients with essential thrombocythemia and acute coronary syndrome.

作者信息

Doesch Christina, Krämer Björn, Geisler Tobias, May Andreas E, Kroeber Stefan-Martin, Kandolf Reinhard, Gawaz Meinrad

机构信息

Department of Cardiology and Cardiovascular Disease, Otfried-Müller-Str. 10, Tuebingen, 72076, Germany.

出版信息

J Thromb Thrombolysis. 2008 Apr;25(2):193-7. doi: 10.1007/s11239-007-0082-0. Epub 2007 Aug 14.

DOI:10.1007/s11239-007-0082-0

PMID:17701105

Abstract

Essential thrombocythemia (ET) is an acquired clonal hematological stem-cell disorder that is characterized by a persistent increase in platelet count over 600,000/microl and elevated megakaryocyte levels in the bone marrow. Patients with ET are on the one hand at risk of thrombosis and on the other hand of hemorrhagic events especially in patients with very high platelet accounts. We report two illustrative cases with ET and acute coronary syndrome from our recent clinical experience illustrating the challenges in the antithrombotic treatment of these patients.

摘要

原发性血小板增多症（ET）是一种获得性克隆性血液系统干细胞疾病，其特征是血小板计数持续超过600,000/微升，骨髓中巨核细胞水平升高。ET患者一方面有血栓形成的风险，另一方面有出血事件的风险，尤其是血小板计数非常高的患者。我们根据最近的临床经验报告了两例ET合并急性冠状动脉综合征的病例，说明了这些患者抗血栓治疗中的挑战。