Brepoels Lieselot, Stroobants Sigrid, De Wever Walter, Spaepen Karoline, Vandenberghe Peter, Thomas Jose, Uyttebroeck Anne, Mortelmans Luc, De Wolf-Peeters Christiane, Verhoef Gregor
Department of Nuclear Medicine, University Hospital Gasthuisberg and Catholic University Leuven, Leuven, Belgium.
Leuk Lymphoma. 2007 Aug;48(8):1522-30. doi: 10.1080/10428190701474365.
Until recently, response assessment in patients with lymphoma was primarily performed by computed tomography (CT). Based on CT, International Workshop Criteria (IWC) were developed and widely used. Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) is a more sensitive and specific imaging technique for the detection of residual disease in lymphoma, and Revised Integrated International Workshop Criteria (IWC + PET) were recently proposed by the members of the International Harmonization Project (IHP), which combine both imaging techniques. We determined whether these new IWC + PET-criteria, can more accurately predict outcome compared to IWC-criteria in aggressive and indolent non-Hodgkin's lymphoma (NHL), and therefore correlated IWC and IWC + PET response with time-to-next-treatment (TNT) in 69 patients with NHL. We demonstrated that IWC + PET-guidelines are highly recommended over IWC-guidelines for patients with potentially-curable and routinely FDG-avid lymphoma. In contrast, no additional value of IWC + PET was demonstrated in a small group of patients with incurable histological subtypes.
直到最近，淋巴瘤患者的疗效评估主要通过计算机断层扫描（CT）进行。基于CT制定了国际研讨会标准（IWC）并被广泛应用。氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）是检测淋巴瘤残留病灶更敏感、特异的成像技术，国际协调项目（IHP）成员最近提出了修订后的综合国际研讨会标准（IWC + PET），该标准结合了两种成像技术。我们确定与IWC标准相比，这些新的IWC + PET标准是否能更准确地预测侵袭性和惰性非霍奇金淋巴瘤（NHL）的预后，因此对69例NHL患者的IWC和IWC + PET反应与下次治疗时间（TNT）进行了相关性分析。我们证明，对于具有潜在治愈可能且常规FDG摄取阳性的淋巴瘤患者，强烈推荐使用IWC + PET指南而非IWC指南。相比之下，在一小部分组织学亚型无法治愈的患者中，未证明IWC + PET具有额外价值。
