Han Xiao-Hua, Liu Li-Yun, Jing Hong, Liu Tie-Ying, Zhao Yong-Qiang, Shang Yun-Xiao
Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2007 Aug;9(4):347-50.
To study the relationship between the changes of inflammation-associated factors, C-reactive protein (CRP), procalcitonin (PCT), erythrocyte sedimentation rate (ESR), white blood cell (WBC) and neutrophils, and the severity in children with Mycoplasma pneomoniae pneumonia (MPP).
Ninety-two children with acute MPP consisting of 52 cases with concomitant systemic inflammation response syndrome (SIRS) and 40 cases without SIRS were enrolled in this study. The 52 cases with concomitant SIRS were classified into two groups based on the severity of SIRS: mild SIRS (n=25) and severe SIRS (n=27). CRP, PCT, ESR and WBC count and the percentage of neutrophils (NE%) were detected on admission and one week after anti-inflammation treatment.
All of patients showed increased serum CRP contents at admission. The serum CRP contents were the highest in the severe SIRS group, followed by the mild SIRS and non-SIRS groups on admission (P < 0.05 or 0.01). The serum CRP contents were reduced in all of patients after 1-week treatment. The severe SIRS group still demonstrated higher serum CRP contents than the non-SIRS and the mild SIRS groups (P < 0.01). The severe SIRS group had increased serum PCT contents on admission, which were significantly higher than those of the mild SIRS and non-SIRS groups (P < 0.01). After 1-week treatment, the serum PCT contents were reduced in the severe SIRS group but remained higher than in the mild SIRS and non-SIRS groups (P < 0.01). ESR increased significantly in the severe SIRS group than in the mild SIRS and non-SIRS groups on admission (P < 0.01). One-week treatment did not significantly decrease ESR in all three groups. The WBC count and NE% in the mild and severe SIRS groups were significantly higher than in the non-SIRS group and the severe SIRS group had higher WBC count and NE% than the mild SIRS group on admission (P < 0.05). The WBC count and NE% decreased after 1-week treatment in the mild and severe SIRS groups (P < 0.05). One inflammation-associated factor (only CRP) increase was predominant in the non-SIRS group (65%), 2 factors increase in the mild SIRS group (56%), and three or more factors increase in the severe SIRS group (70.4%).
The detection of inflammation-associated factors, CRP, PCT, ESR, WBC and neutrophils, are valuable to the evaluation of severity in MPP.
研究炎症相关因子C反应蛋白（CRP）、降钙素原（PCT）、红细胞沉降率（ESR）、白细胞（WBC）及中性粒细胞与小儿支原体肺炎（MPP）严重程度的关系。
选取92例急性MPP患儿，其中52例伴有全身炎症反应综合征（SIRS），40例不伴有SIRS。将52例伴有SIRS的患儿根据SIRS严重程度分为两组：轻度SIRS组（n = 25）和重度SIRS组（n = 27）。于入院时及抗炎治疗1周后检测CRP、PCT、ESR、WBC计数及中性粒细胞百分比（NE%）。
所有患儿入院时血清CRP含量均升高。入院时重度SIRS组血清CRP含量最高，其次为轻度SIRS组和非SIRS组（P < 0.05或0.01）。治疗1周后所有患儿血清CRP含量均降低。重度SIRS组血清CRP含量仍高于非SIRS组和轻度SIRS组（P < 0.01）。重度SIRS组入院时血清PCT含量升高，显著高于轻度SIRS组和非SIRS组（P < 0.01）。治疗1周后，重度SIRS组血清PCT含量降低，但仍高于轻度SIRS组和非SIRS组（P < 0.01）。入院时重度SIRS组ESR较轻度SIRS组和非SIRS组显著升高（P < 0.01）。治疗1周后三组ESR均无显著下降。轻度和重度SIRS组入院时WBC计数及NE%显著高于非SIRS组，且重度SIRS组入院时WBC计数及NE%高于轻度SIRS组（P < 0.05）。轻度和重度SIRS组治疗1周后WBC计数及NE%下降（P < 0.05）。非SIRS组以1种炎症相关因子（仅CRP）升高为主（65%），轻度SIRS组以2种因子升高为主（56%），重度SIRS组以3种或更多因子升高为主（70.4%）。
检测炎症相关因子CRP、PCT、ESR、WBC及中性粒细胞对评估MPP严重程度有重要价值。
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