Freund G, Dürschmied D, Zhou Q, Richter S, Macharzina R, Haas R, Becherer A, Bode C, Hehrlein C
Department of Cardiology/Angiology, University Clinics of Freiburg, Germany.
Vasa. 2007 May;36(2):96-9. doi: 10.1024/0301-1526.36.2.96.
Pseudoaneurysm is a common complication of cardiac catheterization and coronary intervention with an incidence of 2% even in experienced centers.
In a feasibility study conducted between December 2004 and February 2006 we enrolled 76 patients consecutively to receive local thrombin injection (mean 329 IU; range 100-800 IU) into the aneurysma sac.
Ultrasound guided thrombotic occlusion of pseudoaneurysms was successful after one injection in 83% of the patients, 17% of the patients required more than one injection. The overall success rate of the procedure was 98,9%. No peripheral embolisation of thrombin was noted during any injection and we registered no other complication that needed any further intervention.
We conclude that ultrasound guided occlusion of pseudoaneurysms using thrombin injection with a success rate of the procedure of 98,9% is feasible and safe.
假性动脉瘤是心脏导管插入术和冠状动脉介入治疗的常见并发症，即使在经验丰富的中心，其发生率也为2%。
在2004年12月至2006年2月进行的一项可行性研究中，我们连续纳入76例患者，向动脉瘤腔内注射局部凝血酶（平均329国际单位；范围100 - 800国际单位）。
83%的患者在一次注射后超声引导下假性动脉瘤血栓形成闭塞成功，17%的患者需要多次注射。该操作的总体成功率为98.9%。在任何一次注射过程中均未发现凝血酶外周栓塞，且我们未记录到任何需要进一步干预的其他并发症。
我们得出结论，超声引导下使用凝血酶注射闭塞假性动脉瘤，该操作成功率为98.9%，是可行且安全的。
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