5-羟色胺（1A）受体的膜组织与功能
Membrane organization and function of the serotonin(1A) receptor.
作者信息
Kalipatnapu Shanti, Chattopadhyay Amitabha
机构信息
Divisionof Biological Sciences, University of California, San Diego, La Jolla, CA 92093-0377, USA.
出版信息
Cell Mol Neurobiol. 2007 Dec;27(8):1097-116. doi: 10.1007/s10571-007-9189-2. Epub 2007 Aug 21.
(1) The serotonin(1A) receptor is a G-protein coupled receptor involved in several cognitive, behavioral, and developmental functions. It binds the neurotransmitter serotonin and signals across the membrane through its interactions with heterotrimeric G-proteins. (2) Lipid-protein interactions in membranes play an important role in the assembly, stability, and function of membrane proteins. The role of membrane environment in serotonin(1A) receptor function is beginning to be addressed by exploring the consequences of lipid manipulations on the ligand binding and G-protein coupling of serotonin(1A) receptors, the ability to functionally solubilize the serotonin(1A) receptor, and the factors influencing the membrane organization of the serotonin(1A) receptor. (3) Recent developments involving the application of detergent-based and detergent-free approaches to understand the membrane organization of the serotonin(1A) receptor under conditions of ligand activation and modulation of membrane lipid content, with an emphasis on membrane cholesterol, are described.
（1）5-羟色胺（1A）受体是一种G蛋白偶联受体，参与多种认知、行为和发育功能。它与神经递质5-羟色胺结合，并通过与异源三聚体G蛋白的相互作用在膜上传递信号。（2）膜中的脂-蛋白相互作用在膜蛋白的组装、稳定性和功能中起重要作用。通过探索脂质操作对5-羟色胺（1A）受体的配体结合和G蛋白偶联的影响、功能性溶解5-羟色胺（1A）受体的能力以及影响5-羟色胺（1A）受体膜组织的因素，膜环境在5-羟色胺（1A）受体功能中的作用正开始得到研究。（3）描述了最近的进展，这些进展涉及应用基于去污剂和无去污剂的方法来了解在配体激活和膜脂质含量调节条件下5-羟色胺（1A）受体的膜组织，重点是膜胆固醇。
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