Thong-Ngam Duangporn, Mahachai Varocha, Kullavanijaya Pinit
Department of Physiology, Faculty of Medicine, Chulalongkorn University Bangkok, Thailand.
J Med Assoc Thai. 2007 Jul;90(7):1406-10.
To determine the incidence of H. pylori recurrent infection after successful eradication in 4-year follow-up study, and to evaluate the influencing factors for re-infection.
Thirty-seven patients (age range 20-74 years; average 49.06 +/- 14.03 years) were recruited of which 64.9% were females. The H. pylori infection was proved to be successfully eradicated in all patients. Annually, urea breath test (UBT) was assessed to determine H. pylori status after eradication. Age, sex, eating habit, water drinking, number of children, and treatment regimens against H. pylori were recorded A breath test was also performed on the patient's spouse.
The H. pylori recurrence occurred in 5/37 (13.51%) of patients observed There were two patients in the first year, one patient each in the second, third, and fourth year The cumulative re-infection rate was 5.41% at 1-year 8.11% at 2-year 10.81% at 3-year and 13.51% at 4-year H. pylori infection of spouse was also frequent (80%). Even if the spouse was infected, 88.89% of patients will remain uninfected after 4-years of H. pylori eradication. No influencing factor for infection recurrence was detected.
The risk of re-infection after H. pylori eradication was low in Thai patients after 4-year follow up. Annual re-infection rate was 3.38%. No dependent factors were associated with a recurrence.
在一项为期4年的随访研究中确定幽门螺杆菌成功根除后的复发感染率，并评估再感染的影响因素。
招募了37例患者（年龄范围20 - 74岁；平均49.06±14.03岁），其中64.9%为女性。所有患者的幽门螺杆菌感染均被证明已成功根除。每年进行尿素呼气试验（UBT）以确定根除后幽门螺杆菌的状态。记录年龄、性别、饮食习惯、饮水情况、子女数量以及抗幽门螺杆菌的治疗方案。还对患者的配偶进行了呼气试验。
在观察的37例患者中，有5例（13.51%）出现幽门螺杆菌复发。第一年有2例，第二、三、四年各有1例。1年时累积再感染率为5.41%，2年时为8.11%，3年时为10.81%，4年时为13.51%。配偶的幽门螺杆菌感染也很常见（80%）。即使配偶被感染，在幽门螺杆菌根除4年后，88.89%的患者仍未感染。未检测到感染复发的影响因素。
在泰国患者中，经过4年随访，幽门螺杆菌根除后再感染的风险较低。年再感染率为3.38%。没有发现与复发相关的依赖因素。
Zotero 插件