急性共济失调、格雷夫斯病和僵人综合征。

Acute ataxia, Graves' disease, and stiff person syndrome.

作者信息

Chia Su-Ynn, Chua Richard, Lo Yew-Long, Wong Meng-Cheong, Chan Ling-Ling, Tan Eng-King

机构信息

Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore.

出版信息

Mov Disord. 2007 Oct 15;22(13):1969-71. doi: 10.1002/mds.21703.

DOI:10.1002/mds.21703

PMID:17712846

Abstract

Stiff person syndrome (SPS) has been associated with autoimmune diseases, such as Type 1 diabetes mellitus and autoimmune thyroid disease (Hashimoto's thyroiditis), among others. The association of SPS with hyperthyroidism is extremely rare. We describe a patient with uncontrolled Graves' disease and undiagnosed SPS, who presented initially with acute ataxia simulating a cerebrovascular accident. Initiation of immunosuppressive therapy dramatically improved the patient's Graves' disease within 2 weeks but the neurological symptoms were not alleviated after a follow-up period of 3 years.

摘要

僵人综合征（SPS）与自身免疫性疾病有关，如1型糖尿病和自身免疫性甲状腺疾病（桥本甲状腺炎）等。SPS与甲状腺功能亢进的关联极为罕见。我们描述了一名患有未控制的格雷夫斯病且未被诊断出SPS的患者，该患者最初表现为类似脑血管意外的急性共济失调。免疫抑制治疗开始后，患者的格雷夫斯病在2周内显著改善，但经过3年的随访，神经症状并未缓解。