使用新型生物活性线圈进行动脉瘤的血管内栓塞：与裸铂金线圈的配对分析。
Endovascular occlusion of aneurysms using a new bioactive coil: a matched pair analysis with bare platinum coils.
作者信息
Bendszus Martin, Bartsch Andreas J, Solymosi Laszlo
出版信息
Stroke. 2007 Oct;38(10):2855-7. doi: 10.1161/STROKEAHA.107.489088. Epub 2007 Aug 23.
BACKGROUND AND PURPOSE
To assess safety and efficacy data of a new bioactive coil (Cerecyte) which is loaded with polyglycolic acid on the inside of the coil.
METHODS
Fifty-four patients harboring 55 aneurysms were treated with Cerecyte coils. These aneurysms were matched in localization and size with aneurysms treated with bare platinum coils.
RESULTS
Periprocedural complications and handling did not differ between both groups. Initial aneurysm occlusion was comparable in both treatment groups. At 6 months angiographic follow-up, the aneurysms occluded with Cerecyte coils had a higher chance for complete occlusion (P=0.045) and tended to a lower retreatment rate (P=0.056).
CONCLUSIONS
Cerecyte coils are as safe as bare platinum coils in the endovascular occlusion of aneurysms. This matched pair analysis indicates a higher occlusion rate of aneurysms occluded with Cerecyte coils.
背景与目的
评估一种新型生物活性线圈（Cerecyte）的安全性和有效性数据，该线圈内部装载有聚乙醇酸。
方法
54例患有55个动脉瘤的患者接受了Cerecyte线圈治疗。这些动脉瘤在位置和大小上与接受裸铂线圈治疗的动脉瘤相匹配。
结果
两组的围手术期并发症和操作情况无差异。两个治疗组的初始动脉瘤闭塞情况相当。在6个月的血管造影随访中，使用Cerecyte线圈闭塞的动脉瘤完全闭塞的几率更高（P = 0.045），且再次治疗率有降低趋势（P = 0.056）。
结论
在动脉瘤的血管内闭塞治疗中，Cerecyte线圈与裸铂线圈一样安全。这种配对分析表明，使用Cerecyte线圈闭塞的动脉瘤闭塞率更高。
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