Cahir Marie, Ardis Tara C, Elliott Jennifer J, Kelly Christopher B, Reynolds Gavin P, Cooper Stephen J
Division of Psychiatry and Neuroscience, Queen's University Belfast, Northern Ireland, UK.
Eur Neuropsychopharmacol. 2008 May;18(5):317-22. doi: 10.1016/j.euroneuro.2007.07.006. Epub 2007 Aug 24.
Dietary induced acute tryptophan depletion (ATD) is used to reduce central serotonergic function and to investigate the role of serotonin (5-HT) in psychiatric illness. In healthy volunteers ATD produces working memory deficits and decreases mood in some studies. Brain-derived neurotrophic factor (BDNF) plays a role in both cognition and in the regulation of mood; however, the possible contribution of central BDNF changes to the effects of ATD has not been examined. Therefore, using a rat model we have examined the effect of amino acid mixture-induced ATD on plasma and central BDNF protein levels. ATD significantly reduced free-plasma TRP by 79% and central hippocampal 5-HT by 35% when compared to controls. However, plasma or central BDNF protein levels in the hippocampus and midbrain were not significantly altered by ATD. These results suggest that changes in central BDNF do not contribute to the cognitive or mood effects of ATD.
饮食诱导的急性色氨酸耗竭（ATD）用于降低中枢5-羟色胺能功能，并研究5-羟色胺（5-HT）在精神疾病中的作用。在一些研究中，ATD会使健康志愿者出现工作记忆缺陷并降低情绪。脑源性神经营养因子（BDNF）在认知和情绪调节中均起作用；然而，中枢BDNF变化对ATD效应的可能影响尚未得到研究。因此，我们使用大鼠模型研究了氨基酸混合物诱导的ATD对血浆和中枢BDNF蛋白水平的影响。与对照组相比，ATD使游离血浆色氨酸（TRP）显著降低79%，使中枢海马5-HT降低35%。然而，海马体和中脑中的血浆或中枢BDNF蛋白水平并未因ATD而发生显著改变。这些结果表明，中枢BDNF的变化对ATD的认知或情绪效应没有影响。
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