静脉注射免疫球蛋白成功治疗一例皮肌炎/系统性红斑狼疮重叠综合征合并结核病患者。

Successful treatment with intravenous immunoglobulins in a patient affected by dermatomyositis/systemic lupus erythematosus overlap syndrome and tuberculosis.

作者信息

Luzi Giuseppe, Diamanti Andrea Picchianti, Germano Valentina, Laganà Bruno, Di Rosa Roberta, Salemi Simonetta, Stoppacciaro Antonella, D'Amelio Raffaele

机构信息

Sapienza University of Rome, 2nd School of Medicine, S. Andrea University Hospital, Department of Medical Sciences, Via di Grottarossa 1039, 00189 Roma, Italy.

出版信息

Clin Immunol. 2007 Nov;125(2):127-30. doi: 10.1016/j.clim.2007.07.009. Epub 2007 Aug 27.

DOI:10.1016/j.clim.2007.07.009

PMID:17720626

Abstract

The case of a 56-year-old woman, with a previous history of systemic lupus erythematosus (SLE), later diagnosed as also affected by active dermatomyositis (DM) associated with tuberculosis (TB) is reported. Since TB is a contra-indication to receive immunosuppressive therapy for DM/SLE, intravenous immunoglobulins (IVIG) with low-dose steroids and anti-TB therapy were administered with excellent clinical results. This report underlines the crucial role of IVIG in the treatment of critical patients suffering from connective tissue disorders associated with severe infections.

摘要

报告了一例56岁女性病例，该患者既往有系统性红斑狼疮（SLE）病史，后来被诊断同时患有活动性皮肌炎（DM）并伴有肺结核（TB）。由于结核病是接受DM/SLE免疫抑制治疗的禁忌证，因此给予静脉注射免疫球蛋白（IVIG）、低剂量类固醇和抗结核治疗，临床效果极佳。本报告强调了IVIG在治疗患有与严重感染相关的结缔组织疾病的重症患者中的关键作用。