Kodjoh N, Hountondji A, Addra B
Unité d'Endoscopie Digestive, Centre National Hospitalier et Universitaire, Cotonou, République du Benin.
Ann Gastroenterol Hepatol (Paris). 1991 Nov;27(6):261-7.
The authors analyse the results of esophago-gastro-duodenal fibroscopy in 930 symptomatic patients. Ninety one per cent of them had lesions. Inflammatory pathology was predominant: esophagitis, gastritis and duodenitis were seen in 21.5%, 47% and 29.08% respectively of the patients investigated. Gastritis accompanied 75.13% of cases of esophagitis and 76.4% of duodenitis, and was associated with the demonstration of the presence of Helicobater pylori in gastric biopsies in 56.41% of patients with that lesion. The relatively high incidence of carcinoma of the esophagus (2.7%) is a particular feature of this study, while that of carcinoma of the stomach (1%) was in accordance with classical data. Duodenal ulcer was found in 18% of patients as compared with 5.16% for gastric ulcer. From a pathophysiological standpoint, mention is made of traditional diet (hot, highly spiced), self-medication and intestinal parasite infestation in causing inflammatory lesions. Finally, emphasis is placed upon the role of Helicobacter infection in the development of chronic gastritis. The high rate of infection with this organism and its involvement in the mechanisms of duodenal ulcerogenesis could explain the high incidence of duodenal ulcers in our group and in studies emanating from developing countries.
作者分析了930例有症状患者的食管-胃-十二指肠纤维内镜检查结果。其中91%有病变。炎症性病变占主导:食管炎、胃炎和十二指肠炎分别见于21.5%、47%和29.08%的受检患者。胃炎伴随75.13%的食管炎病例和76.4%的十二指肠炎病例,并且在56.41%有该病变的患者中,胃炎与胃活检中幽门螺杆菌的检出有关。食管癌相对较高的发病率(2.7%)是本研究的一个特点,而胃癌的发病率(1%)与经典数据相符。十二指肠溃疡见于18%的患者,而胃溃疡为5.16%。从病理生理学角度来看,提到了传统饮食(热、辛辣)、自我用药和肠道寄生虫感染导致炎症性病变。最后,强调了幽门螺杆菌感染在慢性胃炎发展中的作用。该病原体的高感染率及其参与十二指肠溃疡发生机制,可能解释了我们研究组以及来自发展中国家的研究中十二指肠溃疡的高发病率。