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[采用“墨西哥方法”进行异基因造血干细胞移植八年]

[Eight years using the "Mexican method" for allogeneic hematopoietic stem cell transplants].

作者信息

Ruiz-Argüelles Guillermo J, Gómez-Almaguer David, Ruiz-Delgado Guillermo J, del Carmen Tarin-Arzaga Luz

机构信息

Centro de Hematología y Medicina Interna, Clinica Ruiz de Puebla, Puebla, México.

出版信息

Gac Med Mex. 2007 May-Jun;143(3):231-5.

Abstract

In the past eight years, in Mexico and in other developing countries, over 350 patients have undergone allogeneic hematopoietic stem cell transplants using a non-myeloablative conditioning regimen developed in Mexico and based on international standards. The so called "Mexican method" to conduct allogeneic stem cell transplants is endowed with certain advantages which make it affordable and in turn, available to individuals living in resource-poor countries. The best results using this method have been observed among patients with stage 1 chronic myelogenous leukemia and aplastic anemia. The less favourable results have been observed among patients with acute lymphoblastic leukemia; mild to moderate results have been reported among patients with acute myelogenous leukemia. The "Mexican method" to conduct hematopoietic cells allografting has resulted not only in turning this method accessible to patients in developing countries, but also it has witnessed an increase in the academic activities of physicians from these countries involved in the field.

摘要

在过去八年里,在墨西哥和其他发展中国家,超过350名患者接受了使用墨西哥研发的、基于国际标准的非清髓性预处理方案进行的异基因造血干细胞移植。这种进行异基因干细胞移植的所谓“墨西哥方法”具有某些优势,使其价格可承受,进而可供生活在资源匮乏国家的个人使用。使用该方法取得的最佳结果见于1期慢性髓性白血病和再生障碍性贫血患者。在急性淋巴细胞白血病患者中观察到的结果较差;在急性髓性白血病患者中报告的结果为轻度至中度。进行造血细胞同种异体移植的“墨西哥方法”不仅使发展中国家的患者能够采用这种方法,而且也见证了这些国家参与该领域的医生学术活动的增加。

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