Lamb Louise, Pereira John Xavier, Shir Yoram
Pain Centre, McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.
Pain Manag Nurs. 2007 Sep;8(3):130-8. doi: 10.1016/j.pmn.2007.05.002.
Methadone treatment in chronic pain patients is still limited owing to misconceptions about addiction, safety, and its unique pharmacokinetic and pharmacodynamic properties. Nevertheless, patients with chronic noncancer pain are frequently treated with methadone at our Pain Centre either as the first opioid of choice, for specific pain conditions, or as a second-line opioid in patients developing tolerance or intractable side effects with other opioids. The aim of this study was to examine whether a nurse case management program of chronic pain patients treated with methadone is feasible and safe in trying to improve patients' care in an ambulatory setting. This program consisted of three phases: initial primary education session, telephone follow-up during methadone titration, and a subsequent maintenance period. The nurse case manager functioned autonomously and when required reported to and consulted the physician. The study included 75 subjects and was done over a nine-month period by completing follow-up questionnaires for every call. Of a total of 194 recorded calls, 41% were unscheduled. Forty-four percent of phone calls resulted in a methadone increase and 11% led to a decrease or cessation of methadone. No patients developed serious morbidity or mortality. Fifty-seven percent of patients were either satisfied or very satisfied with their treatment. A nurse-led case management program of methadone in chronic pain patients can improve patient care in an ambulatory setting.
由于对成瘾、安全性以及其独特的药代动力学和药效学特性存在误解,美沙酮在慢性疼痛患者中的治疗应用仍然有限。尽管如此,在我们的疼痛中心,慢性非癌性疼痛患者经常接受美沙酮治疗,要么作为首选阿片类药物用于特定疼痛状况,要么作为二线阿片类药物用于对其他阿片类药物产生耐受性或出现难治性副作用的患者。本研究的目的是检验针对接受美沙酮治疗的慢性疼痛患者的护士病例管理项目在改善门诊环境下患者护理方面是否可行且安全。该项目包括三个阶段:初始的初级教育课程、美沙酮滴定期间的电话随访以及随后的维持期。护士病例管理者自主开展工作,并在需要时向医生汇报并咨询。该研究纳入了75名受试者,通过在每次电话随访时填写后续问卷,历时九个月完成。在总共194次记录的电话随访中,41%为非计划内的。44%的电话随访导致美沙酮剂量增加,11%导致美沙酮剂量减少或停用。没有患者出现严重的发病情况或死亡。57%的患者对其治疗感到满意或非常满意。由护士主导的针对慢性疼痛患者的美沙酮病例管理项目能够改善门诊环境下的患者护理。