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[食源性肉毒中毒的诊断难点——病例报告与文献综述]

[Diagnostic difficulties in foodborne botulism--case reports and literature review].

作者信息

Chwaluk Paweł, Chwaluk Agnieszka

机构信息

Oddział Chorób Wewnetrznych, Wojewódzkiego Szpitala Specjalistycznego w Białej Podlaskiej.

出版信息

Przegl Lek. 2007;64(4-5):348-51.

Abstract

Food borne botulism is a relatively rare clinical syndrome, which symptomatology is generally highly distinctive. The physicians of various specialties should be familiar with the symptoms of botulism because its sings concern the nervous system, the organ of sight and the gastrointestinal system. In older persons with coexisting chronic diseases some symptoms of botulism may be not distinctive or may mimic exacerbation of early existing diseases. The handbook descriptions present the food borne botulism as dramatic and often deadly disease. However in some cases this disease can have mild course and poor symptomatology. Two cases of food borne botulism with different clinical course are presented in this paper, when the correct diagnosis was established with delay. A 78-year-old man was admitted with the symptoms of pneumonia and dizziness of uncertain aetiology. The diagnosis of food borne botulism was established in 10th day of hospital stay, when the most symptoms were not present. Despite of such late diagnosis and relatively good patient's condition a therapy with antitoxin was administrated. The second case reports a 70-year-old man with chronic heart failure, diabetes and obesity, when the delay of correct diagnosis was about of 24 hours. Despite of relatively early antitoxin administration and intensive supportive care patient died in 11th day of hospital stay.

摘要

食源性肉毒中毒是一种相对罕见的临床综合征,其症状通常具有高度特异性。各专业的医生都应熟悉肉毒中毒的症状,因为其症状涉及神经系统、视觉器官和胃肠道系统。在患有并存慢性病的老年人中,肉毒中毒的一些症状可能不具特异性,或可能类似原有疾病的加重。手册描述将食源性肉毒中毒视为一种严重且往往致命的疾病。然而,在某些情况下,这种疾病可能病程较轻且症状不典型。本文介绍了两例食源性肉毒中毒病例,其临床病程不同,确诊时均有延迟。一名78岁男性因病因不明的肺炎和头晕入院。在住院第10天确诊为食源性肉毒中毒,此时大部分症状已不存在。尽管诊断较晚且患者状况相对良好,但仍给予了抗毒素治疗。第二例报告了一名患有慢性心力衰竭、糖尿病和肥胖症的70岁男性,确诊延迟约24小时。尽管抗毒素给药相对较早且给予了强化支持治疗,但患者仍在住院第11天死亡。

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